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Thyroid hormone inhibition of the prolactin response to thyrotropin-releasing hormone.
J Clin Invest. 1973 Sep; 52(9):2324-9.JCI

Abstract

The influence of serum triiodothyronine (T(3)) and thyroxine (T(4)) concentrations on the release of prolactin in man was studied by determining the prolactin response to synthetic thyrotropin-releasing hormone (TRH) in hypothyroid and hyperthyroid patients before and after correction of their serum thyroid hormone abnormalities. The maximum increment in serum prolactin above the basal level (maximum Delta prolactin) was used as the index of response to TRH. In 12 patients with primary hypothyroidism, the maximum Delta prolactin in response to TRH fell from 100.5+/-29.1 ng/ml (mean +/-SEM) before treatment to 36.1+/-6.0 ng/ml (P < 0.01) during the 4th wk of treatment with 30 mug T(3) + 120 mug T(4) daily. The mean serum T(3) level increased from 57+/-8 to 138+/-10 ng/100 ml, and the mean serum T(4) level increased from 3.0+/-0.4 to 7.2+/-0.4 mug/100 ml during this treatment. In eight normal subjects the maximum Deltaprolactin in response to TRH was not significantly different during the 4th wk of treatment with 30 mug T(3) + 120 mug T(4) daily from the response before treatment. In 10 patients with hyperthyroidism, the maximum Deltaprolactin in response to TRH increased from 14.2+/-2.9 ng/ml before treatment to 46.9+/-6.7 ng/ml (P < 0.001) during antithyroid treatment. The mean serum T(3) level fell from 313+/-47 to 90+/-8 ng/100 ml, and the mean serum T(4) level fell from 20.8+/-2.5 to 6.8+/-0.6 mug/100 ml during this treatment. These results show that changes from normal serum levels of T(3) and T(4) are associated with changes in prolactin responses to TRH; subnormal serum levels of T(3) and T(4) increase TRH-induced prolactin release, whereas substantially higher than normal serum levels of T(3) and T(4) inhibit this release.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

4199418

Citation

Snyder, P J., et al. "Thyroid Hormone Inhibition of the Prolactin Response to Thyrotropin-releasing Hormone." The Journal of Clinical Investigation, vol. 52, no. 9, 1973, pp. 2324-9.
Snyder PJ, Jacobs LS, Utiger RD, et al. Thyroid hormone inhibition of the prolactin response to thyrotropin-releasing hormone. J Clin Invest. 1973;52(9):2324-9.
Snyder, P. J., Jacobs, L. S., Utiger, R. D., & Daughaday, W. H. (1973). Thyroid hormone inhibition of the prolactin response to thyrotropin-releasing hormone. The Journal of Clinical Investigation, 52(9), 2324-9.
Snyder PJ, et al. Thyroid Hormone Inhibition of the Prolactin Response to Thyrotropin-releasing Hormone. J Clin Invest. 1973;52(9):2324-9. PubMed PMID: 4199418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thyroid hormone inhibition of the prolactin response to thyrotropin-releasing hormone. AU - Snyder,P J, AU - Jacobs,L S, AU - Utiger,R D, AU - Daughaday,W H, PY - 1973/9/1/pubmed PY - 1973/9/1/medline PY - 1973/9/1/entrez SP - 2324 EP - 9 JF - The Journal of clinical investigation JO - J Clin Invest VL - 52 IS - 9 N2 - The influence of serum triiodothyronine (T(3)) and thyroxine (T(4)) concentrations on the release of prolactin in man was studied by determining the prolactin response to synthetic thyrotropin-releasing hormone (TRH) in hypothyroid and hyperthyroid patients before and after correction of their serum thyroid hormone abnormalities. The maximum increment in serum prolactin above the basal level (maximum Delta prolactin) was used as the index of response to TRH. In 12 patients with primary hypothyroidism, the maximum Delta prolactin in response to TRH fell from 100.5+/-29.1 ng/ml (mean +/-SEM) before treatment to 36.1+/-6.0 ng/ml (P < 0.01) during the 4th wk of treatment with 30 mug T(3) + 120 mug T(4) daily. The mean serum T(3) level increased from 57+/-8 to 138+/-10 ng/100 ml, and the mean serum T(4) level increased from 3.0+/-0.4 to 7.2+/-0.4 mug/100 ml during this treatment. In eight normal subjects the maximum Deltaprolactin in response to TRH was not significantly different during the 4th wk of treatment with 30 mug T(3) + 120 mug T(4) daily from the response before treatment. In 10 patients with hyperthyroidism, the maximum Deltaprolactin in response to TRH increased from 14.2+/-2.9 ng/ml before treatment to 46.9+/-6.7 ng/ml (P < 0.001) during antithyroid treatment. The mean serum T(3) level fell from 313+/-47 to 90+/-8 ng/100 ml, and the mean serum T(4) level fell from 20.8+/-2.5 to 6.8+/-0.6 mug/100 ml during this treatment. These results show that changes from normal serum levels of T(3) and T(4) are associated with changes in prolactin responses to TRH; subnormal serum levels of T(3) and T(4) increase TRH-induced prolactin release, whereas substantially higher than normal serum levels of T(3) and T(4) inhibit this release. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/4199418/Thyroid_hormone_inhibition_of_the_prolactin_response_to_thyrotropin_releasing_hormone_ L2 - https://doi.org/10.1172/JCI107421 DB - PRIME DP - Unbound Medicine ER -