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The effect of dexamethasone on TSH and prolactin secretion after TRH stimulation.
Can Med Assoc J. 1974 Dec 07; 111(11):1195-7.CM

Abstract

Serum thyrotropin (TSH) and prolactin levels were measured after intravenous administration of 400 mug of synthetic thyrotropin-releasing hormone (TRH) in 13 normal subjects and six hypothyroid patients before and after three days of administration of dexamethasone 2 mg per day. In the normal subjects dexamethasone suppressed baseline serum levels and secretion of TSH after TRH stimulation. On the other hand, it had no effect on the hypothyroid patients. In the control group dexamethasone also suppressed baseline serum levels but not secretion of prolactin after TRH stimulation. Dexamethasone had no effect on prolactin levels in the hypothyroid group. It is concluded that in normal patients short-term administration of dexamethasone has an inhibitory effect on TSH secretion at the pituitary level. As for prolactin, our results could indicate that TRH is a more potent stimulator of prolactin secretion than of TSH secretion, or that TSH and prolactin pituitary thresholds for TRH are different.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

4215558

Citation

Dussault, J H.. "The Effect of Dexamethasone On TSH and Prolactin Secretion After TRH Stimulation." Canadian Medical Association Journal, vol. 111, no. 11, 1974, pp. 1195-7.
Dussault JH. The effect of dexamethasone on TSH and prolactin secretion after TRH stimulation. Can Med Assoc J. 1974;111(11):1195-7.
Dussault, J. H. (1974). The effect of dexamethasone on TSH and prolactin secretion after TRH stimulation. Canadian Medical Association Journal, 111(11), 1195-7.
Dussault JH. The Effect of Dexamethasone On TSH and Prolactin Secretion After TRH Stimulation. Can Med Assoc J. 1974 Dec 7;111(11):1195-7. PubMed PMID: 4215558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of dexamethasone on TSH and prolactin secretion after TRH stimulation. A1 - Dussault,J H, PY - 1974/12/7/pubmed PY - 1974/12/7/medline PY - 1974/12/7/entrez SP - 1195 EP - 7 JF - Canadian Medical Association journal JO - Can Med Assoc J VL - 111 IS - 11 N2 - Serum thyrotropin (TSH) and prolactin levels were measured after intravenous administration of 400 mug of synthetic thyrotropin-releasing hormone (TRH) in 13 normal subjects and six hypothyroid patients before and after three days of administration of dexamethasone 2 mg per day. In the normal subjects dexamethasone suppressed baseline serum levels and secretion of TSH after TRH stimulation. On the other hand, it had no effect on the hypothyroid patients. In the control group dexamethasone also suppressed baseline serum levels but not secretion of prolactin after TRH stimulation. Dexamethasone had no effect on prolactin levels in the hypothyroid group. It is concluded that in normal patients short-term administration of dexamethasone has an inhibitory effect on TSH secretion at the pituitary level. As for prolactin, our results could indicate that TRH is a more potent stimulator of prolactin secretion than of TSH secretion, or that TSH and prolactin pituitary thresholds for TRH are different. SN - 0008-4409 UR - https://www.unboundmedicine.com/medline/citation/4215558/The_effect_of_dexamethasone_on_TSH_and_prolactin_secretion_after_TRH_stimulation_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/4215558/ DB - PRIME DP - Unbound Medicine ER -