TY - JOUR T1 - The effect of dexamethasone on TSH and prolactin secretion after TRH stimulation. A1 - Dussault,J H, PY - 1974/12/7/pubmed PY - 1974/12/7/medline PY - 1974/12/7/entrez SP - 1195 EP - 7 JF - Canadian Medical Association journal JO - Can Med Assoc J VL - 111 IS - 11 N2 - Serum thyrotropin (TSH) and prolactin levels were measured after intravenous administration of 400 mug of synthetic thyrotropin-releasing hormone (TRH) in 13 normal subjects and six hypothyroid patients before and after three days of administration of dexamethasone 2 mg per day. In the normal subjects dexamethasone suppressed baseline serum levels and secretion of TSH after TRH stimulation. On the other hand, it had no effect on the hypothyroid patients. In the control group dexamethasone also suppressed baseline serum levels but not secretion of prolactin after TRH stimulation. Dexamethasone had no effect on prolactin levels in the hypothyroid group. It is concluded that in normal patients short-term administration of dexamethasone has an inhibitory effect on TSH secretion at the pituitary level. As for prolactin, our results could indicate that TRH is a more potent stimulator of prolactin secretion than of TSH secretion, or that TSH and prolactin pituitary thresholds for TRH are different. SN - 0008-4409 UR - https://www.unboundmedicine.com/medline/citation/4215558/The_effect_of_dexamethasone_on_TSH_and_prolactin_secretion_after_TRH_stimulation_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/4215558/ DB - PRIME DP - Unbound Medicine ER -