Tags

Type your tag names separated by a space and hit enter

Effect of metoclopramide on guinea pig stomach: critical dependence on intrinsic stores of acetylcholine.
Gastroenterology. 1979 Mar; 76(3):492-6.G

Abstract

This study is concerned with an investigation of the hypothesis that metoclopramide enhances the contractile activity of the guinea pig antrum by increasing acetylcholine release from the postganglionic cholinergic nerve ending. Longitudinal muscle strips were stimulated repetitively (200 microseconds pulses, 20 Hz, supra maximal current) for 2 hr in the presence of hemicholinium-3 (200 micron). Pretreatment in this manner produced a mean reduction of 50% in the acetylcholine content, when compared with that in repetitively stimulated control strips not incubated with hemicholinium-3. In the hemicholinium-3-treated strips the normal excitatory response to metoclopramide (60 micrometer) was prevented. Only a small reduction in response to metoclopramide was detected in strips which were incubated with hemicholinium-3 but not stimulated repetitively, and in which there was no significant change in acetylcholine content. The stimulant effect of metoclopramide depends, therefore, upon maintenance of intrinsic stores of acetylcholine.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

428704

Citation

Hay, A M., and W K. Man. "Effect of Metoclopramide On Guinea Pig Stomach: Critical Dependence On Intrinsic Stores of Acetylcholine." Gastroenterology, vol. 76, no. 3, 1979, pp. 492-6.
Hay AM, Man WK. Effect of metoclopramide on guinea pig stomach: critical dependence on intrinsic stores of acetylcholine. Gastroenterology. 1979;76(3):492-6.
Hay, A. M., & Man, W. K. (1979). Effect of metoclopramide on guinea pig stomach: critical dependence on intrinsic stores of acetylcholine. Gastroenterology, 76(3), 492-6.
Hay AM, Man WK. Effect of Metoclopramide On Guinea Pig Stomach: Critical Dependence On Intrinsic Stores of Acetylcholine. Gastroenterology. 1979;76(3):492-6. PubMed PMID: 428704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of metoclopramide on guinea pig stomach: critical dependence on intrinsic stores of acetylcholine. AU - Hay,A M, AU - Man,W K, PY - 1979/3/1/pubmed PY - 1979/3/1/medline PY - 1979/3/1/entrez SP - 492 EP - 6 JF - Gastroenterology JO - Gastroenterology VL - 76 IS - 3 N2 - This study is concerned with an investigation of the hypothesis that metoclopramide enhances the contractile activity of the guinea pig antrum by increasing acetylcholine release from the postganglionic cholinergic nerve ending. Longitudinal muscle strips were stimulated repetitively (200 microseconds pulses, 20 Hz, supra maximal current) for 2 hr in the presence of hemicholinium-3 (200 micron). Pretreatment in this manner produced a mean reduction of 50% in the acetylcholine content, when compared with that in repetitively stimulated control strips not incubated with hemicholinium-3. In the hemicholinium-3-treated strips the normal excitatory response to metoclopramide (60 micrometer) was prevented. Only a small reduction in response to metoclopramide was detected in strips which were incubated with hemicholinium-3 but not stimulated repetitively, and in which there was no significant change in acetylcholine content. The stimulant effect of metoclopramide depends, therefore, upon maintenance of intrinsic stores of acetylcholine. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/428704/Effect_of_metoclopramide_on_guinea_pig_stomach:_critical_dependence_on_intrinsic_stores_of_acetylcholine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508579000500 DB - PRIME DP - Unbound Medicine ER -