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C-Peptide and insulin secretion in Pima Indians and Caucasians: constant fractional hepatic extraction over a wide range of insulin concentrations and in obesity.
J Clin Endocrinol Metab. 1979 Apr; 48(4):594-8.JC

Abstract

Peripheral serum insulin and C-peptide concentrations during oral glucose tolerance tests were measured in 10 nondiabetic Pima Indians and 10 nondiabetic Caucasians with varying degrees of obesity. Although both insulin and C-peptide levels were elevated in the Indians compared to the Caucasians (p less than 0.05), hepatic insulin extraction, measured by comparing the C-peptide to insulin ratios, was similar over a wide range of insulin concentrations in both groups. The ratios of C-peptide to insulin were independent of the degree of obesity. These studies indicate that the peripheral hyperinsulinemia in Pima Indians and obese subjects is due in general to pancreatic hypersecretion rather than to diminished hepatic extraction of insulin.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

429504

Citation

Savage, P J., et al. "C-Peptide and Insulin Secretion in Pima Indians and Caucasians: Constant Fractional Hepatic Extraction Over a Wide Range of Insulin Concentrations and in Obesity." The Journal of Clinical Endocrinology and Metabolism, vol. 48, no. 4, 1979, pp. 594-8.
Savage PJ, Flock EV, Mako ME, et al. C-Peptide and insulin secretion in Pima Indians and Caucasians: constant fractional hepatic extraction over a wide range of insulin concentrations and in obesity. J Clin Endocrinol Metab. 1979;48(4):594-8.
Savage, P. J., Flock, E. V., Mako, M. E., Blix, P. M., Rubenstein, A. H., & Bennett, P. H. (1979). C-Peptide and insulin secretion in Pima Indians and Caucasians: constant fractional hepatic extraction over a wide range of insulin concentrations and in obesity. The Journal of Clinical Endocrinology and Metabolism, 48(4), 594-8.
Savage PJ, et al. C-Peptide and Insulin Secretion in Pima Indians and Caucasians: Constant Fractional Hepatic Extraction Over a Wide Range of Insulin Concentrations and in Obesity. J Clin Endocrinol Metab. 1979;48(4):594-8. PubMed PMID: 429504.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - C-Peptide and insulin secretion in Pima Indians and Caucasians: constant fractional hepatic extraction over a wide range of insulin concentrations and in obesity. AU - Savage,P J, AU - Flock,E V, AU - Mako,M E, AU - Blix,P M, AU - Rubenstein,A H, AU - Bennett,P H, PY - 1979/4/1/pubmed PY - 1979/4/1/medline PY - 1979/4/1/entrez SP - 594 EP - 8 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 48 IS - 4 N2 - Peripheral serum insulin and C-peptide concentrations during oral glucose tolerance tests were measured in 10 nondiabetic Pima Indians and 10 nondiabetic Caucasians with varying degrees of obesity. Although both insulin and C-peptide levels were elevated in the Indians compared to the Caucasians (p less than 0.05), hepatic insulin extraction, measured by comparing the C-peptide to insulin ratios, was similar over a wide range of insulin concentrations in both groups. The ratios of C-peptide to insulin were independent of the degree of obesity. These studies indicate that the peripheral hyperinsulinemia in Pima Indians and obese subjects is due in general to pancreatic hypersecretion rather than to diminished hepatic extraction of insulin. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/429504/C_Peptide_and_insulin_secretion_in_Pima_Indians_and_Caucasians:_constant_fractional_hepatic_extraction_over_a_wide_range_of_insulin_concentrations_and_in_obesity_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-48-4-594 DB - PRIME DP - Unbound Medicine ER -