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Effects of a dopamine antagonist on the release of gonadotropin and prolactin in normal women and women with hyperprolactinemic anovulation.
J Clin Endocrinol Metab. 1979 Apr; 48(4):718-20.JC

Abstract

Administration of a dopamine (DA) antagonist, metoclopramide (MCP) resulted in dose-related acute increments of circulating levels of LH and FSH in patients with hyperprolactinemic anovulation due to pituitary microadenoma but not in normal cycling women during the early follicular phase. Concomitant PRL responses to MCP in hyperprolactinemic patients were 1/10 those observed in the cycling women. These findings suggest a relative DA excess at the hypothalamic LRF neurons and a relative DA deficiency at the adenoma lactotroph of hyperprolactinemic patients as compared to cycling women.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

429515

Citation

Quigley, M E., et al. "Effects of a Dopamine Antagonist On the Release of Gonadotropin and Prolactin in Normal Women and Women With Hyperprolactinemic Anovulation." The Journal of Clinical Endocrinology and Metabolism, vol. 48, no. 4, 1979, pp. 718-20.
Quigley ME, Judd SJ, Gilliland GB, et al. Effects of a dopamine antagonist on the release of gonadotropin and prolactin in normal women and women with hyperprolactinemic anovulation. J Clin Endocrinol Metab. 1979;48(4):718-20.
Quigley, M. E., Judd, S. J., Gilliland, G. B., & Yen, S. S. (1979). Effects of a dopamine antagonist on the release of gonadotropin and prolactin in normal women and women with hyperprolactinemic anovulation. The Journal of Clinical Endocrinology and Metabolism, 48(4), 718-20.
Quigley ME, et al. Effects of a Dopamine Antagonist On the Release of Gonadotropin and Prolactin in Normal Women and Women With Hyperprolactinemic Anovulation. J Clin Endocrinol Metab. 1979;48(4):718-20. PubMed PMID: 429515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a dopamine antagonist on the release of gonadotropin and prolactin in normal women and women with hyperprolactinemic anovulation. AU - Quigley,M E, AU - Judd,S J, AU - Gilliland,G B, AU - Yen,S S, PY - 1979/4/1/pubmed PY - 1979/4/1/medline PY - 1979/4/1/entrez SP - 718 EP - 20 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 48 IS - 4 N2 - Administration of a dopamine (DA) antagonist, metoclopramide (MCP) resulted in dose-related acute increments of circulating levels of LH and FSH in patients with hyperprolactinemic anovulation due to pituitary microadenoma but not in normal cycling women during the early follicular phase. Concomitant PRL responses to MCP in hyperprolactinemic patients were 1/10 those observed in the cycling women. These findings suggest a relative DA excess at the hypothalamic LRF neurons and a relative DA deficiency at the adenoma lactotroph of hyperprolactinemic patients as compared to cycling women. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/429515/Effects_of_a_dopamine_antagonist_on_the_release_of_gonadotropin_and_prolactin_in_normal_women_and_women_with_hyperprolactinemic_anovulation_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-48-4-718 DB - PRIME DP - Unbound Medicine ER -