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Dopaminergic control of the septal-hippocampal cholinergic pathway.
J Pharmacol Exp Ther. 1979 Mar; 208(3):476-9.JP

Abstract

Apomorphine given subcutaneously is known to decrease the turnover rate of acetylcholine (TR(ACh) in the hippocampus. Blockade of dopaminergic receptors by intraseptal haloperidol or destruction of dopaminergic terminals by intraseptal 6-hydroxydopamine results in an increase in TR(ACh) in the hippocampus. Specific destruction of the dopaminergic neurons projecting to the septum by the injection of 6-hydroxydopamine into the A10 mesencephalic cell group also results in an increased TR(ACh) in the hippocampus. None of the above treatments affects TR(ACh) in the cortex. Thus, it appears that dopaminergic neurons exert a tonic inhibitory effect on the ACh metabolism of the septal-hippocampal pathway, but do not affect that of cholinergic neurons projecting from the septum to the cortex. It can be inferred that this decrease in the rate of metabolism may be associated with a regulation of the rate of neuronal firing.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

430364

Citation

Robinson, S E., et al. "Dopaminergic Control of the Septal-hippocampal Cholinergic Pathway." The Journal of Pharmacology and Experimental Therapeutics, vol. 208, no. 3, 1979, pp. 476-9.
Robinson SE, Malthe-Sørenssen D, Wood PL, et al. Dopaminergic control of the septal-hippocampal cholinergic pathway. J Pharmacol Exp Ther. 1979;208(3):476-9.
Robinson, S. E., Malthe-Sørenssen, D., Wood, P. L., & Commissiong, J. (1979). Dopaminergic control of the septal-hippocampal cholinergic pathway. The Journal of Pharmacology and Experimental Therapeutics, 208(3), 476-9.
Robinson SE, et al. Dopaminergic Control of the Septal-hippocampal Cholinergic Pathway. J Pharmacol Exp Ther. 1979;208(3):476-9. PubMed PMID: 430364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopaminergic control of the septal-hippocampal cholinergic pathway. AU - Robinson,S E, AU - Malthe-Sørenssen,D, AU - Wood,P L, AU - Commissiong,J, PY - 1979/3/1/pubmed PY - 1979/3/1/medline PY - 1979/3/1/entrez SP - 476 EP - 9 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 208 IS - 3 N2 - Apomorphine given subcutaneously is known to decrease the turnover rate of acetylcholine (TR(ACh) in the hippocampus. Blockade of dopaminergic receptors by intraseptal haloperidol or destruction of dopaminergic terminals by intraseptal 6-hydroxydopamine results in an increase in TR(ACh) in the hippocampus. Specific destruction of the dopaminergic neurons projecting to the septum by the injection of 6-hydroxydopamine into the A10 mesencephalic cell group also results in an increased TR(ACh) in the hippocampus. None of the above treatments affects TR(ACh) in the cortex. Thus, it appears that dopaminergic neurons exert a tonic inhibitory effect on the ACh metabolism of the septal-hippocampal pathway, but do not affect that of cholinergic neurons projecting from the septum to the cortex. It can be inferred that this decrease in the rate of metabolism may be associated with a regulation of the rate of neuronal firing. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/430364/Dopaminergic_control_of_the_septal_hippocampal_cholinergic_pathway_ L2 - https://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=430364 DB - PRIME DP - Unbound Medicine ER -