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Basal and pentagastrin-stimulated acid secretion in newborn human infants.
Pediatr Res. 1979 Jan; 13(1):36-7.PR

Abstract

Basal and pentagastrin-stimulated gastric acid secretion was measured in 26 healthy newborn infants on the 1st and 2nd days of life. Basal acid outputs (BAO) on day 1 (0.378 mEq/hr) and day 2 (0.388 mEq/hr) were similar and not significantly different from the maximal acid outputs (MAO) on day 1 (0.413 mEq/hr) and day 2 (0.452 mEq/hr). When calculated on a mEq/kg/hr basis, BAO on day 1 was 0.110 with an MAO of 0.122. The BAO on day 2 was 0.114 with an MAO of 0.133. Fasting serum gastrin levels obtained before the acid studies on each day were elevated (mean, day 1 = 100 pg/ml; mean, day 2 = 108 pg/ml). These findings suggest that either gastric acid secretion in the newborn is maximal under basal condition or that newborn parietal cells are unresponsive to pentagastrin on day 1 and 2 of life.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

432000

Citation

Euler, A R., et al. "Basal and Pentagastrin-stimulated Acid Secretion in Newborn Human Infants." Pediatric Research, vol. 13, no. 1, 1979, pp. 36-7.
Euler AR, Byrne WJ, Meis PJ, et al. Basal and pentagastrin-stimulated acid secretion in newborn human infants. Pediatr Res. 1979;13(1):36-7.
Euler, A. R., Byrne, W. J., Meis, P. J., Leake, R. D., & Ament, M. E. (1979). Basal and pentagastrin-stimulated acid secretion in newborn human infants. Pediatric Research, 13(1), 36-7.
Euler AR, et al. Basal and Pentagastrin-stimulated Acid Secretion in Newborn Human Infants. Pediatr Res. 1979;13(1):36-7. PubMed PMID: 432000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Basal and pentagastrin-stimulated acid secretion in newborn human infants. AU - Euler,A R, AU - Byrne,W J, AU - Meis,P J, AU - Leake,R D, AU - Ament,M E, PY - 1979/1/1/pubmed PY - 1979/1/1/medline PY - 1979/1/1/entrez SP - 36 EP - 7 JF - Pediatric research JO - Pediatr Res VL - 13 IS - 1 N2 - Basal and pentagastrin-stimulated gastric acid secretion was measured in 26 healthy newborn infants on the 1st and 2nd days of life. Basal acid outputs (BAO) on day 1 (0.378 mEq/hr) and day 2 (0.388 mEq/hr) were similar and not significantly different from the maximal acid outputs (MAO) on day 1 (0.413 mEq/hr) and day 2 (0.452 mEq/hr). When calculated on a mEq/kg/hr basis, BAO on day 1 was 0.110 with an MAO of 0.122. The BAO on day 2 was 0.114 with an MAO of 0.133. Fasting serum gastrin levels obtained before the acid studies on each day were elevated (mean, day 1 = 100 pg/ml; mean, day 2 = 108 pg/ml). These findings suggest that either gastric acid secretion in the newborn is maximal under basal condition or that newborn parietal cells are unresponsive to pentagastrin on day 1 and 2 of life. SN - 0031-3998 UR - https://www.unboundmedicine.com/medline/citation/432000/Basal_and_pentagastrin_stimulated_acid_secretion_in_newborn_human_infants_ DB - PRIME DP - Unbound Medicine ER -