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Persistence of neutrophil hypersegmentation during recovery from megaloblastic granulopoiesis.
Ann Intern Med. 1979 May; 90(5):757-60.AIM

Abstract

We studied the rate of disappearance of neutrophil hypersegmentation in 23 patients with megaloblastic anemia during therapy with vitamin B12 and folic acid. In 14 patients with uncomplicated megaloblastic anemia, the neutrophil lobe average began to fall towards normal 11.4 +/- 0.3 (SEM) days after treatment was begun and became normal by 13.9 +/- 0.6 days. In nine patients with associated inflammatory disorders, the lobe average returned to normal more rapidly. In six initially neutropenic patients, a five-fold increase in total granulocyte count occurred by the eighth day and a seven-fold increment in the total number of circulating hypersegmented neutrophils. Granulocyte folate concentrations in five folate-deficient patients rose to normal levels within 4 to 7 days of starting therapy. Hypersegmentation thus persists for many days after correction of neutropenia and restoration of normal granulocyte folate levels have occurred. We conclude that cobalamin and folate are needed at two different steps in granulopoiesis.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

434675

Citation

Nath, B J., and J Lindenbaum. "Persistence of Neutrophil Hypersegmentation During Recovery From Megaloblastic Granulopoiesis." Annals of Internal Medicine, vol. 90, no. 5, 1979, pp. 757-60.
Nath BJ, Lindenbaum J. Persistence of neutrophil hypersegmentation during recovery from megaloblastic granulopoiesis. Ann Intern Med. 1979;90(5):757-60.
Nath, B. J., & Lindenbaum, J. (1979). Persistence of neutrophil hypersegmentation during recovery from megaloblastic granulopoiesis. Annals of Internal Medicine, 90(5), 757-60.
Nath BJ, Lindenbaum J. Persistence of Neutrophil Hypersegmentation During Recovery From Megaloblastic Granulopoiesis. Ann Intern Med. 1979;90(5):757-60. PubMed PMID: 434675.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Persistence of neutrophil hypersegmentation during recovery from megaloblastic granulopoiesis. AU - Nath,B J, AU - Lindenbaum,J, PY - 1979/5/1/pubmed PY - 1979/5/1/medline PY - 1979/5/1/entrez SP - 757 EP - 60 JF - Annals of internal medicine JO - Ann Intern Med VL - 90 IS - 5 N2 - We studied the rate of disappearance of neutrophil hypersegmentation in 23 patients with megaloblastic anemia during therapy with vitamin B12 and folic acid. In 14 patients with uncomplicated megaloblastic anemia, the neutrophil lobe average began to fall towards normal 11.4 +/- 0.3 (SEM) days after treatment was begun and became normal by 13.9 +/- 0.6 days. In nine patients with associated inflammatory disorders, the lobe average returned to normal more rapidly. In six initially neutropenic patients, a five-fold increase in total granulocyte count occurred by the eighth day and a seven-fold increment in the total number of circulating hypersegmented neutrophils. Granulocyte folate concentrations in five folate-deficient patients rose to normal levels within 4 to 7 days of starting therapy. Hypersegmentation thus persists for many days after correction of neutropenia and restoration of normal granulocyte folate levels have occurred. We conclude that cobalamin and folate are needed at two different steps in granulopoiesis. SN - 0003-4819 UR - https://www.unboundmedicine.com/medline/citation/434675/Persistence_of_neutrophil_hypersegmentation_during_recovery_from_megaloblastic_granulopoiesis_ L2 - https://www.acpjournals.org/doi/10.7326/0003-4819-90-5-757?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -