TY - JOUR T1 - Stimulation by 6-N,2'-O-dibutyryladenosine 3' :5'-cyclic monophosphate and glucocorticoids of phosphoenolpyruvate carboxykinase in the isolated perfused rat liver. AU - Huttner,W B, AU - Krone,W, AU - Seitz,H J, AU - Tarnowski,W, PY - 1974/9/1/pubmed PY - 1974/9/1/medline PY - 1974/9/1/entrez SP - 691 EP - 8 JF - The Biochemical journal JO - Biochem J VL - 142 IS - 3 N2 - Dibutyryl cyclic AMP stimulated the activity of phosphoenolpyruvate carboxykinase in perfused livers of rats, fed on a low-protein diet, linearly over a 6h period. The enzyme activity was also significantly elevated by dexamethasone, the effect being considerably lower than that of the cyclic nucleotide. Since the time-course of phosphoenolpyruvate carboxykinase activity in response to dibutyryl cyclic AMP resembled that observed after dibutyryl cyclic AMP injection into intact animals, it is suggested that induction of the enzyme in vivo is due to a direct action of the cyclic nucleotide on the liver. Combined administration of dibutyryl cyclic AMP and glucocorticoids did not lead to an additive increase of liver phosphoenolpyruvate carboxykinase activity, either in vivo or in the perfused organ. SN - 0264-6021 UR - https://www.unboundmedicine.com/medline/citation/4377216/Stimulation_by_6_N2'_O_dibutyryladenosine_3'_:5'_cyclic_monophosphate_and_glucocorticoids_of_phosphoenolpyruvate_carboxykinase_in_the_isolated_perfused_rat_liver_ DB - PRIME DP - Unbound Medicine ER -