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Cochlear function and sodium and potassium activated adenosine triphosphatase.
Science. 1967 Aug 25; 157(3791):949-50.Sci

Abstract

The maintenance of the cation gradients between endolymph and perilymph in the cochlea requires the operation of a cation pump. An adenosine triphosphatase system activated by sodium and potassium is present in high activity in the cochlear membranes (tegmentum vasculosum and stria vascularis). The cochlear microphonic potential is inhibited by perilymphatic perfusion of ouabain and erythrophleine. Since the microphonic potential depends on the high concentration of potassium ions in the endolymph, our findings strongly suggest the operation of an adenosine triphosphatase cation pump system activated by sodium and potassium, in the generation of cochlear cation gradients.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

4378052

Citation

Kuijpers, W, et al. "Cochlear Function and Sodium and Potassium Activated Adenosine Triphosphatase." Science (New York, N.Y.), vol. 157, no. 3791, 1967, pp. 949-50.
Kuijpers W, Van der Vleuten AC, Bonting SL. Cochlear function and sodium and potassium activated adenosine triphosphatase. Science. 1967;157(3791):949-50.
Kuijpers, W., Van der Vleuten, A. C., & Bonting, S. L. (1967). Cochlear function and sodium and potassium activated adenosine triphosphatase. Science (New York, N.Y.), 157(3791), 949-50.
Kuijpers W, Van der Vleuten AC, Bonting SL. Cochlear Function and Sodium and Potassium Activated Adenosine Triphosphatase. Science. 1967 Aug 25;157(3791):949-50. PubMed PMID: 4378052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cochlear function and sodium and potassium activated adenosine triphosphatase. AU - Kuijpers,W, AU - Van der Vleuten,A C, AU - Bonting,S L, PY - 1967/8/25/pubmed PY - 1967/8/25/medline PY - 1967/8/25/entrez SP - 949 EP - 50 JF - Science (New York, N.Y.) JO - Science VL - 157 IS - 3791 N2 - The maintenance of the cation gradients between endolymph and perilymph in the cochlea requires the operation of a cation pump. An adenosine triphosphatase system activated by sodium and potassium is present in high activity in the cochlear membranes (tegmentum vasculosum and stria vascularis). The cochlear microphonic potential is inhibited by perilymphatic perfusion of ouabain and erythrophleine. Since the microphonic potential depends on the high concentration of potassium ions in the endolymph, our findings strongly suggest the operation of an adenosine triphosphatase cation pump system activated by sodium and potassium, in the generation of cochlear cation gradients. SN - 0036-8075 UR - https://www.unboundmedicine.com/medline/citation/4378052/Cochlear_function_and_sodium_and_potassium_activated_adenosine_triphosphatase_ L2 - https://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=4378052 DB - PRIME DP - Unbound Medicine ER -