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Hypothalamic-pituitary-ovarian axis in uremic women.
J Lab Clin Med. 1979 Jun; 93(6):1066-72.JL

Abstract

Menstrual abnormalities are common with decreasing renal function and uremia. Maintenance hemodialysis therapy partially corrects some of the abnormalities. Since the pathophysiology of the menstural irregularities is unknown, the secretion of LH, FSH, estrogen, and PRL was studied under basal conditions and after provocative testing in 13 women undergoing chronic maintenance hemodialysis. Elevated LH concentrations were found in all six premenopausal (44.1 +/- 26.4 mlU/ml, normal follicular phase 4 to 30) and seven postmenopausal (246.1 +/- 171.4 mlU/ml, normal 35 to 200) women studied. FSH values were normal both in the premenopausal women (7.9 +/- 4.1 mlU/ml, normal 2 to 20) and in postmenopausal women (88.0 +/- 69.0 mlU/ml, normal 40 to 200). FSH and LH levels did not show typical ovulatory spikes in three of four women studied. Pulsatile hormonal release was absent. The pituitary response to LH-RH was adequate and prolonged, but the response to clomiphene citrate was variable. The study documents the existence of abnormalities at various levels of the hypothalamic-putuitary-ovarian axis.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

438608

Citation

Swamy, A P., et al. "Hypothalamic-pituitary-ovarian Axis in Uremic Women." The Journal of Laboratory and Clinical Medicine, vol. 93, no. 6, 1979, pp. 1066-72.
Swamy AP, Woolf PD, Cestero RV. Hypothalamic-pituitary-ovarian axis in uremic women. J Lab Clin Med. 1979;93(6):1066-72.
Swamy, A. P., Woolf, P. D., & Cestero, R. V. (1979). Hypothalamic-pituitary-ovarian axis in uremic women. The Journal of Laboratory and Clinical Medicine, 93(6), 1066-72.
Swamy AP, Woolf PD, Cestero RV. Hypothalamic-pituitary-ovarian Axis in Uremic Women. J Lab Clin Med. 1979;93(6):1066-72. PubMed PMID: 438608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypothalamic-pituitary-ovarian axis in uremic women. AU - Swamy,A P, AU - Woolf,P D, AU - Cestero,R V, PY - 1979/6/1/pubmed PY - 1979/6/1/medline PY - 1979/6/1/entrez SP - 1066 EP - 72 JF - The Journal of laboratory and clinical medicine JO - J Lab Clin Med VL - 93 IS - 6 N2 - Menstrual abnormalities are common with decreasing renal function and uremia. Maintenance hemodialysis therapy partially corrects some of the abnormalities. Since the pathophysiology of the menstural irregularities is unknown, the secretion of LH, FSH, estrogen, and PRL was studied under basal conditions and after provocative testing in 13 women undergoing chronic maintenance hemodialysis. Elevated LH concentrations were found in all six premenopausal (44.1 +/- 26.4 mlU/ml, normal follicular phase 4 to 30) and seven postmenopausal (246.1 +/- 171.4 mlU/ml, normal 35 to 200) women studied. FSH values were normal both in the premenopausal women (7.9 +/- 4.1 mlU/ml, normal 2 to 20) and in postmenopausal women (88.0 +/- 69.0 mlU/ml, normal 40 to 200). FSH and LH levels did not show typical ovulatory spikes in three of four women studied. Pulsatile hormonal release was absent. The pituitary response to LH-RH was adequate and prolonged, but the response to clomiphene citrate was variable. The study documents the existence of abnormalities at various levels of the hypothalamic-putuitary-ovarian axis. SN - 0022-2143 UR - https://www.unboundmedicine.com/medline/citation/438608/Hypothalamic_pituitary_ovarian_axis_in_uremic_women_ DB - PRIME DP - Unbound Medicine ER -