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Tyrosine transaminase induction by dexamethasone in a new rat liver cell line.
Science. 1970 Nov 20; 170(3960):859-61.Sci

Abstract

A cell line derived from normal, adult rat liver has been established; the cells are similar to hepatocytes, as shown by electron microscopy. The addition of dexamethasone to the culture medium induced a three- to sixfold increase in the specific activity of tyrosine alpha-ketoglutarate transaminase; this increase was inhibited by the simultaneous addition of cycloheximide or actinomycin D. The latter, when added to cells given prior treatment with dexamethasone, further enhanced the transaminase activity. Contact-inhibited cells showed a lower response to dexamethasone than exponentially growing cells.

Authors

Gerschenson LE
No affiliation info available
Andersson M
No affiliation info available
Molson J
No affiliation info available
Okigaki T
No affiliation info available

MeSH

AnimalsCell LineContact InhibitionCulture TechniquesCycloheximideDactinomycinDexamethasoneEnzyme InductionLiverMicroscopy, ElectronRatsTyrosine Transaminase

Pub Type(s)

Journal Article

Language

eng

PubMed ID

4394388

Citation

Gerschenson, L E., et al. "Tyrosine Transaminase Induction By Dexamethasone in a New Rat Liver Cell Line." Science (New York, N.Y.), vol. 170, no. 3960, 1970, pp. 859-61.
Gerschenson LE, Andersson M, Molson J, et al. Tyrosine transaminase induction by dexamethasone in a new rat liver cell line. Science. 1970;170(3960):859-61.
Gerschenson, L. E., Andersson, M., Molson, J., & Okigaki, T. (1970). Tyrosine transaminase induction by dexamethasone in a new rat liver cell line. Science (New York, N.Y.), 170(3960), 859-61.
Gerschenson LE, et al. Tyrosine Transaminase Induction By Dexamethasone in a New Rat Liver Cell Line. Science. 1970 Nov 20;170(3960):859-61. PubMed PMID: 4394388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tyrosine transaminase induction by dexamethasone in a new rat liver cell line. AU - Gerschenson,L E, AU - Andersson,M, AU - Molson,J, AU - Okigaki,T, PY - 1970/11/20/pubmed PY - 1970/11/20/medline PY - 1970/11/20/entrez SP - 859 EP - 61 JF - Science (New York, N.Y.) JO - Science VL - 170 IS - 3960 N2 - A cell line derived from normal, adult rat liver has been established; the cells are similar to hepatocytes, as shown by electron microscopy. The addition of dexamethasone to the culture medium induced a three- to sixfold increase in the specific activity of tyrosine alpha-ketoglutarate transaminase; this increase was inhibited by the simultaneous addition of cycloheximide or actinomycin D. The latter, when added to cells given prior treatment with dexamethasone, further enhanced the transaminase activity. Contact-inhibited cells showed a lower response to dexamethasone than exponentially growing cells. SN - 0036-8075 UR - https://www.unboundmedicine.com/medline/citation/4394388/Tyrosine_transaminase_induction_by_dexamethasone_in_a_new_rat_liver_cell_line_ DB - PRIME DP - Unbound Medicine ER -