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Galactorrhea and pituitary tumors in postpill and non-postpill secondary amenorrhea.
Am J Obstet Gynecol. 1979 May 01; 134(1):45-8.AJ

Abstract

One hundred sixty-seven women with secondary amenorrhea were observed from six months to four years. In 66 patients, the amenorrhea followed the discontinuation of oral contraceptives (postpill) while in the remaining 101 the amenorrhea was not temporally pill related (non-postpill). Galactorrhea was present in 43 (65%) of those with postpill amenorrhea and in 32 (32%) of those with non-postpill amenorrhea (p less than 0.001). Tomography of the sella turcica was performed in the 75 women with galactorrhea and in the 35 without galactorrhea who did not have withdrawal uterine bleeding following progesterone administration and who had low or normal serum follicle-stimulating hormone levels (hypothalamic-pituitary failure). Forty of the 75 patients with amenorrhea and galactorrhea had radiographic evidence of a pituitary tumor whereas only eight of 35 patients with hypothalamic-pituitary failure without galactorrhea had an abnormal sella turcica (p less than 0.01). The incidence of radiographic abnormalities in those with galactorrhea was similar in both the postpill and non-postpill groups.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

443307

Citation

March, C M., et al. "Galactorrhea and Pituitary Tumors in Postpill and Non-postpill Secondary Amenorrhea." American Journal of Obstetrics and Gynecology, vol. 134, no. 1, 1979, pp. 45-8.
March CM, Mishell DR, Kletzky OA, et al. Galactorrhea and pituitary tumors in postpill and non-postpill secondary amenorrhea. Am J Obstet Gynecol. 1979;134(1):45-8.
March, C. M., Mishell, D. R., Kletzky, O. A., Israel, R., Davajan, V., & Nakamura, R. M. (1979). Galactorrhea and pituitary tumors in postpill and non-postpill secondary amenorrhea. American Journal of Obstetrics and Gynecology, 134(1), 45-8.
March CM, et al. Galactorrhea and Pituitary Tumors in Postpill and Non-postpill Secondary Amenorrhea. Am J Obstet Gynecol. 1979 May 1;134(1):45-8. PubMed PMID: 443307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Galactorrhea and pituitary tumors in postpill and non-postpill secondary amenorrhea. AU - March,C M, AU - Mishell,D R,Jr AU - Kletzky,O A, AU - Israel,R, AU - Davajan,V, AU - Nakamura,R M, PY - 1979/5/1/pubmed PY - 2001/3/28/medline PY - 1979/5/1/entrez SP - 45 EP - 8 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 134 IS - 1 N2 - One hundred sixty-seven women with secondary amenorrhea were observed from six months to four years. In 66 patients, the amenorrhea followed the discontinuation of oral contraceptives (postpill) while in the remaining 101 the amenorrhea was not temporally pill related (non-postpill). Galactorrhea was present in 43 (65%) of those with postpill amenorrhea and in 32 (32%) of those with non-postpill amenorrhea (p less than 0.001). Tomography of the sella turcica was performed in the 75 women with galactorrhea and in the 35 without galactorrhea who did not have withdrawal uterine bleeding following progesterone administration and who had low or normal serum follicle-stimulating hormone levels (hypothalamic-pituitary failure). Forty of the 75 patients with amenorrhea and galactorrhea had radiographic evidence of a pituitary tumor whereas only eight of 35 patients with hypothalamic-pituitary failure without galactorrhea had an abnormal sella turcica (p less than 0.01). The incidence of radiographic abnormalities in those with galactorrhea was similar in both the postpill and non-postpill groups. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/443307/Galactorrhea_and_pituitary_tumors_in_postpill_and_non_postpill_secondary_amenorrhea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9378(79)90794-4 DB - PRIME DP - Unbound Medicine ER -