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Epidemiology of alcohol and cancer.
Cancer Res. 1979 Jul; 39(7 Pt 2):2840-3.CR

Abstract

There is still insufficient knowledge of the distribution of drinking habits in human populations, and more descriptive surveys are needed. Both prospective and retrospective epidemiological studies indicate that alcohol consumption is a cancer hazard. Prospective studies on excessive drinkers have shown an increased risk for cancer of the mouth, pharynx, larynx, esophagus, liver, and lung. Retrospective studies have confirmed this excess risk. For cancers of the buccal cavity, pharynx, larynx, and esophagus, the effect of drinking has been shown to be associated with the effect of smoking. In the case of esophageal cancer, these two effects are independent, and the observations made are consistent with a multiplicative model. Primary liver cancer is also associated with alcohol consumption, probably by a less direct action; the importance of the impact of alcohol on primary liver cancer is probably underestimated. Animal experiments have not shown that ethanol alone has a carcinogenic effect, and the mechanisms by which alcoholic beverages act on humans remain unknown. The proportion of cancer cases at sites known to be associated with alcohol consumption is approximately 8% in most population groups in the United States. This indicates that a sizeable proportion of cancers is potentially preventable if appropriate action is taken.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

445490

Citation

Tuyns, A J.. "Epidemiology of Alcohol and Cancer." Cancer Research, vol. 39, no. 7 Pt 2, 1979, pp. 2840-3.
Tuyns AJ. Epidemiology of alcohol and cancer. Cancer Res. 1979;39(7 Pt 2):2840-3.
Tuyns, A. J. (1979). Epidemiology of alcohol and cancer. Cancer Research, 39(7 Pt 2), 2840-3.
Tuyns AJ. Epidemiology of Alcohol and Cancer. Cancer Res. 1979;39(7 Pt 2):2840-3. PubMed PMID: 445490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of alcohol and cancer. A1 - Tuyns,A J, PY - 1979/7/1/pubmed PY - 1979/7/1/medline PY - 1979/7/1/entrez SP - 2840 EP - 3 JF - Cancer research JO - Cancer Res. VL - 39 IS - 7 Pt 2 N2 - There is still insufficient knowledge of the distribution of drinking habits in human populations, and more descriptive surveys are needed. Both prospective and retrospective epidemiological studies indicate that alcohol consumption is a cancer hazard. Prospective studies on excessive drinkers have shown an increased risk for cancer of the mouth, pharynx, larynx, esophagus, liver, and lung. Retrospective studies have confirmed this excess risk. For cancers of the buccal cavity, pharynx, larynx, and esophagus, the effect of drinking has been shown to be associated with the effect of smoking. In the case of esophageal cancer, these two effects are independent, and the observations made are consistent with a multiplicative model. Primary liver cancer is also associated with alcohol consumption, probably by a less direct action; the importance of the impact of alcohol on primary liver cancer is probably underestimated. Animal experiments have not shown that ethanol alone has a carcinogenic effect, and the mechanisms by which alcoholic beverages act on humans remain unknown. The proportion of cancer cases at sites known to be associated with alcohol consumption is approximately 8% in most population groups in the United States. This indicates that a sizeable proportion of cancers is potentially preventable if appropriate action is taken. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/445490/Epidemiology_of_alcohol_and_cancer_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=445490 DB - PRIME DP - Unbound Medicine ER -