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Plasma aldosterone, renin activity, and cortisol responses to heat exposure in sodium depleted and repeleted subjects.
Eur J Appl Physiol Occup Physiol. 1979 Apr 12; 41(1):41-50.EJ

Abstract

The effect of 90-min heat exposure (46 degrees C, 35 mbar) on plasma aldosterone (PA) patterns was studied and the respective roles of plasma renin activity (PRA), adrenocorticotropin (ACTH), Na+ and K+ concentrations in the control of PA response were in investigated in eight subjects on a low sodium diet and in five subjects on a high sodium diet. In all subjects, transitory PA increases of varying importance were observed, which were not related to sweat losses (less than 1% bodyweight) or to rectal temperature rise. In sodium-repleted subjects, basal PA and PRA levels as well as heat-induced rises were low (mean PA peak level = 12.62 +/- 1.15 ng/100 ml). They were enhanced by sodium depletion and PA reached a mean peak level of 34.07 +/- 2.73 ng/100 ml. But, in both conditions, the heat-induced PA peaks were 3-times higher than the initial levels. PA correlated with PRA in all but one of the sodium-repleted subjects and in 6 of the 8 sodium-depleted subjects. ACTH release, as measured by plasma cortisol (PC) levels, occurred in those subjects who noted an increased feeling of annoyance and discomfort. Thus, PA correlated positively with PC in 4 sodium-depleted subjects. A high sodium intake improved heat-tolerance. Plasma K+ and Na+ concentrations were not significantly modified by exposure to heat. PA increases can occur without concomitant changes in PRA, PC, K+ or Na+, which suggests that an additional factor may play a role in aldosterone regulation during acute heat exposure.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

446470

Citation

Follenius, M, et al. "Plasma Aldosterone, Renin Activity, and Cortisol Responses to Heat Exposure in Sodium Depleted and Repeleted Subjects." European Journal of Applied Physiology and Occupational Physiology, vol. 41, no. 1, 1979, pp. 41-50.
Follenius M, Brandenberger G, Reinhardt B, et al. Plasma aldosterone, renin activity, and cortisol responses to heat exposure in sodium depleted and repeleted subjects. Eur J Appl Physiol Occup Physiol. 1979;41(1):41-50.
Follenius, M., Brandenberger, G., Reinhardt, B., & Simeoni, M. (1979). Plasma aldosterone, renin activity, and cortisol responses to heat exposure in sodium depleted and repeleted subjects. European Journal of Applied Physiology and Occupational Physiology, 41(1), 41-50.
Follenius M, et al. Plasma Aldosterone, Renin Activity, and Cortisol Responses to Heat Exposure in Sodium Depleted and Repeleted Subjects. Eur J Appl Physiol Occup Physiol. 1979 Apr 12;41(1):41-50. PubMed PMID: 446470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma aldosterone, renin activity, and cortisol responses to heat exposure in sodium depleted and repeleted subjects. AU - Follenius,M, AU - Brandenberger,G, AU - Reinhardt,B, AU - Simeoni,M, PY - 1979/4/12/pubmed PY - 1979/4/12/medline PY - 1979/4/12/entrez SP - 41 EP - 50 JF - European journal of applied physiology and occupational physiology JO - Eur J Appl Physiol Occup Physiol VL - 41 IS - 1 N2 - The effect of 90-min heat exposure (46 degrees C, 35 mbar) on plasma aldosterone (PA) patterns was studied and the respective roles of plasma renin activity (PRA), adrenocorticotropin (ACTH), Na+ and K+ concentrations in the control of PA response were in investigated in eight subjects on a low sodium diet and in five subjects on a high sodium diet. In all subjects, transitory PA increases of varying importance were observed, which were not related to sweat losses (less than 1% bodyweight) or to rectal temperature rise. In sodium-repleted subjects, basal PA and PRA levels as well as heat-induced rises were low (mean PA peak level = 12.62 +/- 1.15 ng/100 ml). They were enhanced by sodium depletion and PA reached a mean peak level of 34.07 +/- 2.73 ng/100 ml. But, in both conditions, the heat-induced PA peaks were 3-times higher than the initial levels. PA correlated with PRA in all but one of the sodium-repleted subjects and in 6 of the 8 sodium-depleted subjects. ACTH release, as measured by plasma cortisol (PC) levels, occurred in those subjects who noted an increased feeling of annoyance and discomfort. Thus, PA correlated positively with PC in 4 sodium-depleted subjects. A high sodium intake improved heat-tolerance. Plasma K+ and Na+ concentrations were not significantly modified by exposure to heat. PA increases can occur without concomitant changes in PRA, PC, K+ or Na+, which suggests that an additional factor may play a role in aldosterone regulation during acute heat exposure. SN - 0301-5548 UR - https://www.unboundmedicine.com/medline/citation/446470/Plasma_aldosterone_renin_activity_and_cortisol_responses_to_heat_exposure_in_sodium_depleted_and_repeleted_subjects_ L2 - https://antibodies.cancer.gov/detail/CPTC-Calcyclin-1 DB - PRIME DP - Unbound Medicine ER -