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Biochemical parameters of guinea pig perilymph sampled according to scala and following sound presentation.
Environ Health Perspect. 1974 Aug; 8:157-64.EH

Abstract

Guinea pigs were exposed to sound varying from 2 to 8 kHz in frequency and 80-100 dB (SPL) in intensity for periods of 1 hr. The biochemical parameters, glucose, sodium, total protein, and the glycolytic enzymes, aldolase, phosphohexose isomerase, and total LDH as well as isozymes of the latter were ascertained for blood serum, perilymph, and, in some instances, cerebrospinal fluid. The three enzymes occurred at lower levels in perilymph as compared to blood serum. Except for a small difference in serum total protein, sound presentation incurred no significant effect on any of the above parameters. Definite differences in several metabolites were discerned for perilymph sampled according to scala and which were independent of the respective acoustical treatments. Thus, as compared to the scale tympani, the scala vestibuli perilymph displayed a higher glucose content and a diminished total LDH level and of the latter isozymes, LDH(1) ranged lower and LDH(2), higher. As further evidence pointing to cerebrospinal fluid as the possible origin of perilymph, similarities in glucose contents and LDH isozyme patterns were noted for both fluids.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

4470918

Citation

Gershbein, L L., et al. "Biochemical Parameters of Guinea Pig Perilymph Sampled According to Scala and Following Sound Presentation." Environmental Health Perspectives, vol. 8, 1974, pp. 157-64.
Gershbein LL, Manshio DT, Shurrager PS. Biochemical parameters of guinea pig perilymph sampled according to scala and following sound presentation. Environ Health Perspect. 1974;8:157-64.
Gershbein, L. L., Manshio, D. T., & Shurrager, P. S. (1974). Biochemical parameters of guinea pig perilymph sampled according to scala and following sound presentation. Environmental Health Perspectives, 8, 157-64.
Gershbein LL, Manshio DT, Shurrager PS. Biochemical Parameters of Guinea Pig Perilymph Sampled According to Scala and Following Sound Presentation. Environ Health Perspect. 1974;8:157-64. PubMed PMID: 4470918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biochemical parameters of guinea pig perilymph sampled according to scala and following sound presentation. AU - Gershbein,L L, AU - Manshio,D T, AU - Shurrager,P S, PY - 1974/8/1/pubmed PY - 1974/8/1/medline PY - 1974/8/1/entrez SP - 157 EP - 64 JF - Environmental health perspectives JO - Environ Health Perspect VL - 8 N2 - Guinea pigs were exposed to sound varying from 2 to 8 kHz in frequency and 80-100 dB (SPL) in intensity for periods of 1 hr. The biochemical parameters, glucose, sodium, total protein, and the glycolytic enzymes, aldolase, phosphohexose isomerase, and total LDH as well as isozymes of the latter were ascertained for blood serum, perilymph, and, in some instances, cerebrospinal fluid. The three enzymes occurred at lower levels in perilymph as compared to blood serum. Except for a small difference in serum total protein, sound presentation incurred no significant effect on any of the above parameters. Definite differences in several metabolites were discerned for perilymph sampled according to scala and which were independent of the respective acoustical treatments. Thus, as compared to the scale tympani, the scala vestibuli perilymph displayed a higher glucose content and a diminished total LDH level and of the latter isozymes, LDH(1) ranged lower and LDH(2), higher. As further evidence pointing to cerebrospinal fluid as the possible origin of perilymph, similarities in glucose contents and LDH isozyme patterns were noted for both fluids. SN - 0091-6765 UR - https://www.unboundmedicine.com/medline/citation/4470918/Biochemical_parameters_of_guinea_pig_perilymph_sampled_according_to_scala_and_following_sound_presentation_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/ehp.748157?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -