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Ultrastructure of the gonad in the testicular feminization syndrome.
Pathol Eur. 1974; 9(4):249-57.PE

Abstract

The ultrastructural findings on the gonad from a patient with testicular feminization syndrome (TFS) are reported. One gonad was the site of dysgerminoma. The other was a dysgenetic testis composed of seminiferoud and Sertoli cell tubules and ovarian cortical stroma-like tissue. Ultrastructurally the tubules were lined by immature Sertoli cells and cells indistinguishable from dark ovarian stromal cells. Similar and/or identical cells were found in the ovarian-like stroma and in the interstitial tissue between the tubules. There were mature and immature Leydig cells in the intertubular areas. The ovarian cortical-like tissue contained dark and light cells like the normal ovary. Some of the dark cells contained fat droplets like thecoma cells. All these findings point to the dysgenetic nature of the gonad in the TFS as well as the functional activity and or inactivity of certain cells found in it.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

4477375

Citation

Damjanov, I, and P Drobnjak. "Ultrastructure of the Gonad in the Testicular Feminization Syndrome." Pathologia Europaea, vol. 9, no. 4, 1974, pp. 249-57.
Damjanov I, Drobnjak P. Ultrastructure of the gonad in the testicular feminization syndrome. Pathol Eur. 1974;9(4):249-57.
Damjanov, I., & Drobnjak, P. (1974). Ultrastructure of the gonad in the testicular feminization syndrome. Pathologia Europaea, 9(4), 249-57.
Damjanov I, Drobnjak P. Ultrastructure of the Gonad in the Testicular Feminization Syndrome. Pathol Eur. 1974;9(4):249-57. PubMed PMID: 4477375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultrastructure of the gonad in the testicular feminization syndrome. AU - Damjanov,I, AU - Drobnjak,P, PY - 1974/1/1/pubmed PY - 1974/1/1/medline PY - 1974/1/1/entrez SP - 249 EP - 57 JF - Pathologia Europaea JO - Pathol Eur VL - 9 IS - 4 N2 - The ultrastructural findings on the gonad from a patient with testicular feminization syndrome (TFS) are reported. One gonad was the site of dysgerminoma. The other was a dysgenetic testis composed of seminiferoud and Sertoli cell tubules and ovarian cortical stroma-like tissue. Ultrastructurally the tubules were lined by immature Sertoli cells and cells indistinguishable from dark ovarian stromal cells. Similar and/or identical cells were found in the ovarian-like stroma and in the interstitial tissue between the tubules. There were mature and immature Leydig cells in the intertubular areas. The ovarian cortical-like tissue contained dark and light cells like the normal ovary. Some of the dark cells contained fat droplets like thecoma cells. All these findings point to the dysgenetic nature of the gonad in the TFS as well as the functional activity and or inactivity of certain cells found in it. SN - 0031-2967 UR - https://www.unboundmedicine.com/medline/citation/4477375/Ultrastructure_of_the_gonad_in_the_testicular_feminization_syndrome_ L2 - http://www.diseaseinfosearch.org/result/7031 DB - PRIME DP - Unbound Medicine ER -