Tags

Type your tag names separated by a space and hit enter

Relationship of the reductive metabolism of indicine N-oxide to its antitumor activity.
Res Commun Chem Pathol Pharmacol. 1979 Jun; 24(3):559-69.RC

Abstract

Several pyrrolizidine alkaloids have been demonstrated to have antitumor activity in experimental tumor systems. In general the free base form of the alkaloid exhibits greater biological activity than the corresponding N-oxide and the N-oxide must be metabolized to the base for the subsequent formation of alkylating intermediates. Indicine N-oxide is an exception in that it is a more active antitumor agent than its free base indicine. Studies of the antitumor activity and metabolism of indicine N-oxide, and the closely related compound, heliotrine N-oxide, given orally and intraperitoneally to mice bearing P-388 leukemia, suggest that conversion of indicine N-oxide to indicine is not essential for its antitumor activity.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

451340

Citation

Powis, G, et al. "Relationship of the Reductive Metabolism of Indicine N-oxide to Its Antitumor Activity." Research Communications in Chemical Pathology and Pharmacology, vol. 24, no. 3, 1979, pp. 559-69.
Powis G, Ames MM, Kovach JS. Relationship of the reductive metabolism of indicine N-oxide to its antitumor activity. Res Commun Chem Pathol Pharmacol. 1979;24(3):559-69.
Powis, G., Ames, M. M., & Kovach, J. S. (1979). Relationship of the reductive metabolism of indicine N-oxide to its antitumor activity. Research Communications in Chemical Pathology and Pharmacology, 24(3), 559-69.
Powis G, Ames MM, Kovach JS. Relationship of the Reductive Metabolism of Indicine N-oxide to Its Antitumor Activity. Res Commun Chem Pathol Pharmacol. 1979;24(3):559-69. PubMed PMID: 451340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of the reductive metabolism of indicine N-oxide to its antitumor activity. AU - Powis,G, AU - Ames,M M, AU - Kovach,J S, PY - 1979/6/1/pubmed PY - 1979/6/1/medline PY - 1979/6/1/entrez SP - 559 EP - 69 JF - Research communications in chemical pathology and pharmacology JO - Res Commun Chem Pathol Pharmacol VL - 24 IS - 3 N2 - Several pyrrolizidine alkaloids have been demonstrated to have antitumor activity in experimental tumor systems. In general the free base form of the alkaloid exhibits greater biological activity than the corresponding N-oxide and the N-oxide must be metabolized to the base for the subsequent formation of alkylating intermediates. Indicine N-oxide is an exception in that it is a more active antitumor agent than its free base indicine. Studies of the antitumor activity and metabolism of indicine N-oxide, and the closely related compound, heliotrine N-oxide, given orally and intraperitoneally to mice bearing P-388 leukemia, suggest that conversion of indicine N-oxide to indicine is not essential for its antitumor activity. SN - 0034-5164 UR - https://www.unboundmedicine.com/medline/citation/451340/Relationship_of_the_reductive_metabolism_of_indicine_N_oxide_to_its_antitumor_activity_ DB - PRIME DP - Unbound Medicine ER -