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Studies on the pathogenesis of swine dysentery. I. Characterization of the lesions in colons and colonic segments inoculated with pure cultures or colonic content containing Treponema hyodysenteriae.
Vet Pathol. 1979 Jul; 16(4):450-65.VP

Abstract

Swine dysentery was induced in pigs and in ligated colonic segments by inoculation of pure cultures of, or colonic contents containing, Treponema hyodysenteriae. The mildest changes, best seen in ligated segments 48 or 72 hours after inoculation, were congestion and leucocytic margination in mucosal capillaries and depletion of mucigen from goblet cells lining the base of the crypts of Lieberkühn. Superficial mucosal necrosis and crypt cell hyperplasia were later changes. Perfusion studies with India ink did not demonstrate occlusive mucosal ischemia in acute swine dysentery. Mucosa with lesions of swine dysentery contained at least 10(5) colony forming units of T. hyodysenteriae per gram. Mucosa without lesions had 10(5) or fewer T. hyodysenteriae per gram. Segments with acute swine dysentery were distended with clear mucoid fluid with electrolyte composition indicative of net colonic secretion. No increase in the concentration of volatile fatty acids was detected in content from intact colons or colonic segments with lesions of acute swine dysentery.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

452320

Citation

Wilcock, B P., and H J. Olander. "Studies On the Pathogenesis of Swine Dysentery. I. Characterization of the Lesions in Colons and Colonic Segments Inoculated With Pure Cultures or Colonic Content Containing Treponema Hyodysenteriae." Veterinary Pathology, vol. 16, no. 4, 1979, pp. 450-65.
Wilcock BP, Olander HJ. Studies on the pathogenesis of swine dysentery. I. Characterization of the lesions in colons and colonic segments inoculated with pure cultures or colonic content containing Treponema hyodysenteriae. Vet Pathol. 1979;16(4):450-65.
Wilcock, B. P., & Olander, H. J. (1979). Studies on the pathogenesis of swine dysentery. I. Characterization of the lesions in colons and colonic segments inoculated with pure cultures or colonic content containing Treponema hyodysenteriae. Veterinary Pathology, 16(4), 450-65.
Wilcock BP, Olander HJ. Studies On the Pathogenesis of Swine Dysentery. I. Characterization of the Lesions in Colons and Colonic Segments Inoculated With Pure Cultures or Colonic Content Containing Treponema Hyodysenteriae. Vet Pathol. 1979;16(4):450-65. PubMed PMID: 452320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies on the pathogenesis of swine dysentery. I. Characterization of the lesions in colons and colonic segments inoculated with pure cultures or colonic content containing Treponema hyodysenteriae. AU - Wilcock,B P, AU - Olander,H J, PY - 1979/7/1/pubmed PY - 1979/7/1/medline PY - 1979/7/1/entrez SP - 450 EP - 65 JF - Veterinary pathology JO - Vet. Pathol. VL - 16 IS - 4 N2 - Swine dysentery was induced in pigs and in ligated colonic segments by inoculation of pure cultures of, or colonic contents containing, Treponema hyodysenteriae. The mildest changes, best seen in ligated segments 48 or 72 hours after inoculation, were congestion and leucocytic margination in mucosal capillaries and depletion of mucigen from goblet cells lining the base of the crypts of Lieberkühn. Superficial mucosal necrosis and crypt cell hyperplasia were later changes. Perfusion studies with India ink did not demonstrate occlusive mucosal ischemia in acute swine dysentery. Mucosa with lesions of swine dysentery contained at least 10(5) colony forming units of T. hyodysenteriae per gram. Mucosa without lesions had 10(5) or fewer T. hyodysenteriae per gram. Segments with acute swine dysentery were distended with clear mucoid fluid with electrolyte composition indicative of net colonic secretion. No increase in the concentration of volatile fatty acids was detected in content from intact colons or colonic segments with lesions of acute swine dysentery. SN - 0300-9858 UR - https://www.unboundmedicine.com/medline/citation/452320/Studies_on_the_pathogenesis_of_swine_dysentery__I__Characterization_of_the_lesions_in_colons_and_colonic_segments_inoculated_with_pure_cultures_or_colonic_content_containing_Treponema_hyodysenteriae_ L2 - http://journals.sagepub.com/doi/full/10.1177/030098587901600409?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -