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Ochratoxin A-induced iron deficiency anemia.
Appl Environ Microbiol 1979; 37(3):601-4AE

Abstract

Ochratoxin A at 8 micrograms per g of diet, but not at lower doses, fed to chickens from 1 day to 3 weeks of age resulted in significantly (P less than 0.05) decreased packed blood cell volume and hemoglobin concentration without altering the number of circulating erythrocytes. Serum iron and percentage of transferrin saturation were lowered at 4 and 8 micrograms/g. Therefore, anemia was characteristic of severe ochratoxicosis of young chickens, and the anemia was categorized as a hypochromic-microcytic anemia of the iron deficiency type. These data indicate that ochratoxin A by itself does not cause hemorrhagic anemia syndrome of chickens and that an anemia caused by a nutritional deficiency can be elicited by a mycotoxin.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

453831

Citation

Huff, W E., et al. "Ochratoxin A-induced Iron Deficiency Anemia." Applied and Environmental Microbiology, vol. 37, no. 3, 1979, pp. 601-4.
Huff WE, Chang CF, Warren MF, et al. Ochratoxin A-induced iron deficiency anemia. Appl Environ Microbiol. 1979;37(3):601-4.
Huff, W. E., Chang, C. F., Warren, M. F., & Hamilton, P. B. (1979). Ochratoxin A-induced iron deficiency anemia. Applied and Environmental Microbiology, 37(3), pp. 601-4.
Huff WE, et al. Ochratoxin A-induced Iron Deficiency Anemia. Appl Environ Microbiol. 1979;37(3):601-4. PubMed PMID: 453831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ochratoxin A-induced iron deficiency anemia. AU - Huff,W E, AU - Chang,C F, AU - Warren,M F, AU - Hamilton,P B, PY - 1979/3/1/pubmed PY - 1979/3/1/medline PY - 1979/3/1/entrez SP - 601 EP - 4 JF - Applied and environmental microbiology JO - Appl. Environ. Microbiol. VL - 37 IS - 3 N2 - Ochratoxin A at 8 micrograms per g of diet, but not at lower doses, fed to chickens from 1 day to 3 weeks of age resulted in significantly (P less than 0.05) decreased packed blood cell volume and hemoglobin concentration without altering the number of circulating erythrocytes. Serum iron and percentage of transferrin saturation were lowered at 4 and 8 micrograms/g. Therefore, anemia was characteristic of severe ochratoxicosis of young chickens, and the anemia was categorized as a hypochromic-microcytic anemia of the iron deficiency type. These data indicate that ochratoxin A by itself does not cause hemorrhagic anemia syndrome of chickens and that an anemia caused by a nutritional deficiency can be elicited by a mycotoxin. SN - 0099-2240 UR - https://www.unboundmedicine.com/medline/citation/453831/Ochratoxin_A_induced_iron_deficiency_anemia_ L2 - http://aem.asm.org/cgi/pmidlookup?view=long&pmid=453831 DB - PRIME DP - Unbound Medicine ER -