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Macrocytic anaemia.
Aust Fam Physician. 1979 Apr; 8(4):369, 371-3, 375-8 passim.AF

Abstract

Macrocytosis of red cells is now more easily and precisely detected in the laboratory by the adoption of electronic methods of cell volume measurement. This means the practitioner will be more frequently faced with the problem of what an elevated mean corpuscular volume (MCV) means. Macrocytic anaemia is not synonymous with folate or cobalamin deficiency, there being many causes of non-megaloblastic macrocytosis including excess alcohol, hypothyroidism, and liver disease. The commonest cause is blood regeneration as after a bleed, or in response to a haematinic or in haemolysis, as reticulocytes are large red cells and will raise the MCV. Megaloblastic anaemia, as in folate or cobalamin deficiency, has a normal or low reticulocyte count and a multiplicity of causes which must be identified as the cause may require treatment in its own right as well as the prescription of the required vitamin.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

454310

Citation

Jackson, J M., and R E. Davis. "Macrocytic Anaemia." Australian Family Physician, vol. 8, no. 4, 1979, 369, 371-3, 375-8 passim.
Jackson JM, Davis RE. Macrocytic anaemia. Aust Fam Physician. 1979;8(4):369, 371-3, 375-8 passim.
Jackson, J. M., & Davis, R. E. (1979). Macrocytic anaemia. Australian Family Physician, 8(4), 369, 371-3, 375-8 passim.
Jackson JM, Davis RE. Macrocytic Anaemia. Aust Fam Physician. 1979;8(4):369, 371-3, 375-8 passim. PubMed PMID: 454310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macrocytic anaemia. AU - Jackson,J M, AU - Davis,R E, PY - 1979/4/1/pubmed PY - 1979/4/1/medline PY - 1979/4/1/entrez SP - 369, 371-3, 375-8 passim JF - Australian family physician JO - Aust Fam Physician VL - 8 IS - 4 N2 - Macrocytosis of red cells is now more easily and precisely detected in the laboratory by the adoption of electronic methods of cell volume measurement. This means the practitioner will be more frequently faced with the problem of what an elevated mean corpuscular volume (MCV) means. Macrocytic anaemia is not synonymous with folate or cobalamin deficiency, there being many causes of non-megaloblastic macrocytosis including excess alcohol, hypothyroidism, and liver disease. The commonest cause is blood regeneration as after a bleed, or in response to a haematinic or in haemolysis, as reticulocytes are large red cells and will raise the MCV. Megaloblastic anaemia, as in folate or cobalamin deficiency, has a normal or low reticulocyte count and a multiplicity of causes which must be identified as the cause may require treatment in its own right as well as the prescription of the required vitamin. SN - 0300-8495 UR - https://www.unboundmedicine.com/medline/citation/454310/Macrocytic_anaemia_ DB - PRIME DP - Unbound Medicine ER -