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Quantitative evaluation of the effectiveness of Connaught freeze-dried BCG vaccine in mice and in guineapigs.
Bull World Health Organ 1974; 51(3):283-9BW

Abstract

Although the field trials carried out by the Medical Research Council of Great Britain demonstrated that BCG vaccination can confer a substantial degree of immunity against tuberculous infection, it does not follow that BCG substrains other than the one used for those trials will produce equally favourable results. In fact, there is increasing evidence that different BCG strains may differ widely in their protective potency. The experiments described here further confirm these differences. They also show how the determination of the minimum dose of a BCG vaccine capable of delaying the development of tuberculous infection in mice and in guinea-pigs can yield reproducible data that may help to characterize individual BCG strains.The main purpose of these experiments was to determine the protective potency of Connaught freeze-dried BCG vaccine, lot 140, and to compare it with that of three other BCG vaccines. Marked differences were found with respect to the minimum protective dose for mice or guinea-pigs and the degree of immunity and tuberculin allergy produced in guinea-pigs as shown by the dose-response relationships recorded over a wide dosage range. The results suggest that the Connaught vaccine equals or surpasses the other vaccines in effectiveness.Such tests require a reference BCG vaccine of high protective potency for both animals and man.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

4549351

Citation

Siebenmann, C O., and C Barbara. "Quantitative Evaluation of the Effectiveness of Connaught Freeze-dried BCG Vaccine in Mice and in Guineapigs." Bulletin of the World Health Organization, vol. 51, no. 3, 1974, pp. 283-9.
Siebenmann CO, Barbara C. Quantitative evaluation of the effectiveness of Connaught freeze-dried BCG vaccine in mice and in guineapigs. Bull World Health Organ. 1974;51(3):283-9.
Siebenmann, C. O., & Barbara, C. (1974). Quantitative evaluation of the effectiveness of Connaught freeze-dried BCG vaccine in mice and in guineapigs. Bulletin of the World Health Organization, 51(3), pp. 283-9.
Siebenmann CO, Barbara C. Quantitative Evaluation of the Effectiveness of Connaught Freeze-dried BCG Vaccine in Mice and in Guineapigs. Bull World Health Organ. 1974;51(3):283-9. PubMed PMID: 4549351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative evaluation of the effectiveness of Connaught freeze-dried BCG vaccine in mice and in guineapigs. AU - Siebenmann,C O, AU - Barbara,C, PY - 1974/1/1/pubmed PY - 1974/1/1/medline PY - 1974/1/1/entrez SP - 283 EP - 9 JF - Bulletin of the World Health Organization JO - Bull. World Health Organ. VL - 51 IS - 3 N2 - Although the field trials carried out by the Medical Research Council of Great Britain demonstrated that BCG vaccination can confer a substantial degree of immunity against tuberculous infection, it does not follow that BCG substrains other than the one used for those trials will produce equally favourable results. In fact, there is increasing evidence that different BCG strains may differ widely in their protective potency. The experiments described here further confirm these differences. They also show how the determination of the minimum dose of a BCG vaccine capable of delaying the development of tuberculous infection in mice and in guinea-pigs can yield reproducible data that may help to characterize individual BCG strains.The main purpose of these experiments was to determine the protective potency of Connaught freeze-dried BCG vaccine, lot 140, and to compare it with that of three other BCG vaccines. Marked differences were found with respect to the minimum protective dose for mice or guinea-pigs and the degree of immunity and tuberculin allergy produced in guinea-pigs as shown by the dose-response relationships recorded over a wide dosage range. The results suggest that the Connaught vaccine equals or surpasses the other vaccines in effectiveness.Such tests require a reference BCG vaccine of high protective potency for both animals and man. SN - 0042-9686 UR - https://www.unboundmedicine.com/medline/citation/4549351/Quantitative_evaluation_of_the_effectiveness_of_Connaught_freeze_dried_BCG_vaccine_in_mice_and_in_guineapigs_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/4549351/ DB - PRIME DP - Unbound Medicine ER -