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Two types of Zollinger-Ellison syndrome: immunofluorescent, cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states.
Gut. 1972 Jul; 13(7):501-12.Gut

Abstract

In this survey the antral, pancreatic and, where present, the neoplastic gastrin cells, were studied in eight cases of the Zollinger-Ellison syndrome. The antral G cells alone were studied in one case of Z-E syndrome, seven cases of simple duodenal ulcer, and five cases of pernicious anaemia. The Z-E cases were divided into two numerically equal groups. The first group had ;short' histories, high serum gastrin levels, and profound antral G cell hyperplasia. The second group had ;long' histories, relatively lower serum gastrin levels, normal antral G cells, and either pancreatic D cell hyperplasia or gastrinoma. Antral G cell hyperplasia, with maximal gastrin storage and normal serum gastrin levels, was found in the duodenal ulcer cases. Antral G cell hyperplasia with minimal storage and high serum gastrin levels was observed in the cases of pernicious anaemia. On the basis of our findings we propose that there exist at least two distinct types (or perhaps stages) of the Z-E syndrome. Suggestions for their pathogenesis are offered.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

4560738

Citation

Polak, J M., et al. "Two Types of Zollinger-Ellison Syndrome: Immunofluorescent, Cytochemical and Ultrastructural Studies of the Antral and Pancreatic Gastrin Cells in Different Clinical States." Gut, vol. 13, no. 7, 1972, pp. 501-12.
Polak JM, Stagg B, Pearse AG. Two types of Zollinger-Ellison syndrome: immunofluorescent, cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states. Gut. 1972;13(7):501-12.
Polak, J. M., Stagg, B., & Pearse, A. G. (1972). Two types of Zollinger-Ellison syndrome: immunofluorescent, cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states. Gut, 13(7), 501-12.
Polak JM, Stagg B, Pearse AG. Two Types of Zollinger-Ellison Syndrome: Immunofluorescent, Cytochemical and Ultrastructural Studies of the Antral and Pancreatic Gastrin Cells in Different Clinical States. Gut. 1972;13(7):501-12. PubMed PMID: 4560738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two types of Zollinger-Ellison syndrome: immunofluorescent, cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states. AU - Polak,J M, AU - Stagg,B, AU - Pearse,A G, PY - 1972/7/1/pubmed PY - 1972/7/1/medline PY - 1972/7/1/entrez SP - 501 EP - 12 JF - Gut JO - Gut VL - 13 IS - 7 N2 - In this survey the antral, pancreatic and, where present, the neoplastic gastrin cells, were studied in eight cases of the Zollinger-Ellison syndrome. The antral G cells alone were studied in one case of Z-E syndrome, seven cases of simple duodenal ulcer, and five cases of pernicious anaemia. The Z-E cases were divided into two numerically equal groups. The first group had ;short' histories, high serum gastrin levels, and profound antral G cell hyperplasia. The second group had ;long' histories, relatively lower serum gastrin levels, normal antral G cells, and either pancreatic D cell hyperplasia or gastrinoma. Antral G cell hyperplasia, with maximal gastrin storage and normal serum gastrin levels, was found in the duodenal ulcer cases. Antral G cell hyperplasia with minimal storage and high serum gastrin levels was observed in the cases of pernicious anaemia. On the basis of our findings we propose that there exist at least two distinct types (or perhaps stages) of the Z-E syndrome. Suggestions for their pathogenesis are offered. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/4560738/Two_types_of_Zollinger_Ellison_syndrome:_immunofluorescent_cytochemical_and_ultrastructural_studies_of_the_antral_and_pancreatic_gastrin_cells_in_different_clinical_states_ L2 - https://gut.bmj.com/lookup/pmidlookup?view=long&pmid=4560738 DB - PRIME DP - Unbound Medicine ER -