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An appraisal of tests for severe atrophic gastritis in relatives of patients with pernicious anemia.
Dig Dis Sci. 1979 Mar; 24(3):187-91.DD

Abstract

The sensitivities, specificities, and predictive values of parietal cell antibody, serum gastrin, and serum pepsinogen I (PG I) for severe atrophic gastritis of the oxyntic gland mucosa have been determined in 171 first-degree relatives of 62 patients with pernicious anemia. Parietal cell antibody had the lowest sensitivity (65%), specificity (87%), and predictive value (44%). A low serum PG I and a high serum gastrin had identical specificities (97%), and similar predictive values (84 vs 83%), but the sensitivity of a low serum PG I was greater than that of a high serum gastrin (91 vs 83%). Parietal cell antibody was found in 19 of 148 relatives without severe atrophic gastritis and occurred as an isolated finding in 17. In contrast, 14 of the 15 relatives with severe atrophic gastritis who had parietal cell antibody also had a high serum gastrin and a low serum PG I. A high serum gastrin together with a low serum PG I had a specificity of 100%. The results recommend serum PG I and serum gastrin, but not parietal cell antibody, as tests for severe atrophic gastritis in relatives of patients with pernicious anemia.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

456206

Citation

Varis, K, et al. "An Appraisal of Tests for Severe Atrophic Gastritis in Relatives of Patients With Pernicious Anemia." Digestive Diseases and Sciences, vol. 24, no. 3, 1979, pp. 187-91.
Varis K, Samloff IM, Ihämaki T, et al. An appraisal of tests for severe atrophic gastritis in relatives of patients with pernicious anemia. Dig Dis Sci. 1979;24(3):187-91.
Varis, K., Samloff, I. M., Ihämaki, T., & Siurala, M. (1979). An appraisal of tests for severe atrophic gastritis in relatives of patients with pernicious anemia. Digestive Diseases and Sciences, 24(3), 187-91.
Varis K, et al. An Appraisal of Tests for Severe Atrophic Gastritis in Relatives of Patients With Pernicious Anemia. Dig Dis Sci. 1979;24(3):187-91. PubMed PMID: 456206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An appraisal of tests for severe atrophic gastritis in relatives of patients with pernicious anemia. AU - Varis,K, AU - Samloff,I M, AU - Ihämaki,T, AU - Siurala,M, PY - 1979/3/1/pubmed PY - 1979/3/1/medline PY - 1979/3/1/entrez SP - 187 EP - 91 JF - Digestive diseases and sciences JO - Dig Dis Sci VL - 24 IS - 3 N2 - The sensitivities, specificities, and predictive values of parietal cell antibody, serum gastrin, and serum pepsinogen I (PG I) for severe atrophic gastritis of the oxyntic gland mucosa have been determined in 171 first-degree relatives of 62 patients with pernicious anemia. Parietal cell antibody had the lowest sensitivity (65%), specificity (87%), and predictive value (44%). A low serum PG I and a high serum gastrin had identical specificities (97%), and similar predictive values (84 vs 83%), but the sensitivity of a low serum PG I was greater than that of a high serum gastrin (91 vs 83%). Parietal cell antibody was found in 19 of 148 relatives without severe atrophic gastritis and occurred as an isolated finding in 17. In contrast, 14 of the 15 relatives with severe atrophic gastritis who had parietal cell antibody also had a high serum gastrin and a low serum PG I. A high serum gastrin together with a low serum PG I had a specificity of 100%. The results recommend serum PG I and serum gastrin, but not parietal cell antibody, as tests for severe atrophic gastritis in relatives of patients with pernicious anemia. SN - 0163-2116 UR - https://www.unboundmedicine.com/medline/citation/456206/An_appraisal_of_tests_for_severe_atrophic_gastritis_in_relatives_of_patients_with_pernicious_anemia_ L2 - http://www.diseaseinfosearch.org/result/441 DB - PRIME DP - Unbound Medicine ER -