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Zollinger-Ellison syndrome type 1: clinical and pathological correlations in a case.
Gut. 1973 Jan; 14(1):25-9.Gut

Abstract

Some patients with the Zollinger-Ellison syndrome appear to have hypergastrinaemia and hyperplasia of the antral G cells but no tumour. This subgroup has been classified as Zollinger-Ellison syndrome type 1. We have treated such a patient by vagotomy and antrectomy, the fasting plasma gastrin and acid secretion subsequently returning to normal.A 17-year-old male had a four-year history of duodenal ulcer. Gastric secretion tests showed acid hypersecretion. Fasting plasma gastrin was 8350 pg/ml (normal 50-170 pg/ml). At laparotomy duodenal ulceration was confirmed but no pancreatic or other tumours were found. Truncal vagotomy and antrectomy was performed with distal pancreatectomy. Immunofluorescent staining showed hyperplasia of G cells in the resected antrum but a normal pancreas and duodenum. Six months after operation he was symptom free and acid secretion was reduced by 92%. The fasting plasma gastrin at two months was <50 pg/ml. These findings suggest that type 1 Zollinger-Ellison syndrome may be a clinical entity.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

4571070

Citation

Cowley, D J., et al. "Zollinger-Ellison Syndrome Type 1: Clinical and Pathological Correlations in a Case." Gut, vol. 14, no. 1, 1973, pp. 25-9.
Cowley DJ, Dymock IW, Boyes BE, et al. Zollinger-Ellison syndrome type 1: clinical and pathological correlations in a case. Gut. 1973;14(1):25-9.
Cowley, D. J., Dymock, I. W., Boyes, B. E., Wilson, R. Y., Stagg, B. H., Lewin, M. R., Polak, J. M., & Pearse, A. G. (1973). Zollinger-Ellison syndrome type 1: clinical and pathological correlations in a case. Gut, 14(1), 25-9.
Cowley DJ, et al. Zollinger-Ellison Syndrome Type 1: Clinical and Pathological Correlations in a Case. Gut. 1973;14(1):25-9. PubMed PMID: 4571070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zollinger-Ellison syndrome type 1: clinical and pathological correlations in a case. AU - Cowley,D J, AU - Dymock,I W, AU - Boyes,B E, AU - Wilson,R Y, AU - Stagg,B H, AU - Lewin,M R, AU - Polak,J M, AU - Pearse,A G, PY - 1973/1/1/pubmed PY - 1973/1/1/medline PY - 1973/1/1/entrez SP - 25 EP - 9 JF - Gut JO - Gut VL - 14 IS - 1 N2 - Some patients with the Zollinger-Ellison syndrome appear to have hypergastrinaemia and hyperplasia of the antral G cells but no tumour. This subgroup has been classified as Zollinger-Ellison syndrome type 1. We have treated such a patient by vagotomy and antrectomy, the fasting plasma gastrin and acid secretion subsequently returning to normal.A 17-year-old male had a four-year history of duodenal ulcer. Gastric secretion tests showed acid hypersecretion. Fasting plasma gastrin was 8350 pg/ml (normal 50-170 pg/ml). At laparotomy duodenal ulceration was confirmed but no pancreatic or other tumours were found. Truncal vagotomy and antrectomy was performed with distal pancreatectomy. Immunofluorescent staining showed hyperplasia of G cells in the resected antrum but a normal pancreas and duodenum. Six months after operation he was symptom free and acid secretion was reduced by 92%. The fasting plasma gastrin at two months was <50 pg/ml. These findings suggest that type 1 Zollinger-Ellison syndrome may be a clinical entity. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/4571070/Zollinger_Ellison_syndrome_type_1:_clinical_and_pathological_correlations_in_a_case_ L2 - https://gut.bmj.com/lookup/pmidlookup?view=long&amp;pmid=4571070 DB - PRIME DP - Unbound Medicine ER -