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Pathomorphologic, biochemical, and diagnostic aspects of gastrinomas (Zollinger-Ellison syndrome).
Hum Pathol. 1975 Jan; 6(1):47-76.HP

Abstract

The clinical symptomatology of the Zollinger-Ellison syndrome and the pathologic anatomy of gastrinomas are reviewed. Experience with 17 patients with the Zollinger-Ellison syndrome is presented with special reference to stimulation tests (secretin, glucagon, calcium infusion, test meal) and to localization and immunohistologic, ultrastructural, and biochemical findings in gastrinomas. Multiple hormone production by the tumors is frequent. The ultrastructure and the Sephadex G-50 gel filtration patterns of immunoreactive gastrin in sera and tumors are not uniform and are not related to localization of the tumors in the pancreas or duodenum or to the gastrin concentration. Hyperplasia of the pancreatic islets is a frequent finding in gastrinoma patients, suggesting that hypergastrinemia may stimulate islet growth.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

45919

Citation

Creutzfeldt, W, et al. "Pathomorphologic, Biochemical, and Diagnostic Aspects of Gastrinomas (Zollinger-Ellison Syndrome)." Human Pathology, vol. 6, no. 1, 1975, pp. 47-76.
Creutzfeldt W, Arnold R, Creutzfeldt C, et al. Pathomorphologic, biochemical, and diagnostic aspects of gastrinomas (Zollinger-Ellison syndrome). Hum Pathol. 1975;6(1):47-76.
Creutzfeldt, W., Arnold, R., Creutzfeldt, C., & Track, N. S. (1975). Pathomorphologic, biochemical, and diagnostic aspects of gastrinomas (Zollinger-Ellison syndrome). Human Pathology, 6(1), 47-76.
Creutzfeldt W, et al. Pathomorphologic, Biochemical, and Diagnostic Aspects of Gastrinomas (Zollinger-Ellison Syndrome). Hum Pathol. 1975;6(1):47-76. PubMed PMID: 45919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathomorphologic, biochemical, and diagnostic aspects of gastrinomas (Zollinger-Ellison syndrome). AU - Creutzfeldt,W, AU - Arnold,R, AU - Creutzfeldt,C, AU - Track,N S, PY - 1975/1/1/pubmed PY - 1975/1/1/medline PY - 1975/1/1/entrez SP - 47 EP - 76 JF - Human pathology JO - Hum Pathol VL - 6 IS - 1 N2 - The clinical symptomatology of the Zollinger-Ellison syndrome and the pathologic anatomy of gastrinomas are reviewed. Experience with 17 patients with the Zollinger-Ellison syndrome is presented with special reference to stimulation tests (secretin, glucagon, calcium infusion, test meal) and to localization and immunohistologic, ultrastructural, and biochemical findings in gastrinomas. Multiple hormone production by the tumors is frequent. The ultrastructure and the Sephadex G-50 gel filtration patterns of immunoreactive gastrin in sera and tumors are not uniform and are not related to localization of the tumors in the pancreas or duodenum or to the gastrin concentration. Hyperplasia of the pancreatic islets is a frequent finding in gastrinoma patients, suggesting that hypergastrinemia may stimulate islet growth. SN - 0046-8177 UR - https://www.unboundmedicine.com/medline/citation/45919/Pathomorphologic_biochemical_and_diagnostic_aspects_of_gastrinomas__Zollinger_Ellison_syndrome__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0046-8177(75)80109-2 DB - PRIME DP - Unbound Medicine ER -