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Galactosemia: alterations in sulfate metabolism secondary to galactose-1-phosphate uridyltransferase deficiency.
Science. 1979 Sep 28; 205(4413):1395-7.Sci

Abstract

Cultures of nonmutant as well as galactokinase-deficient fibroblasts incorporate 20 percent more [35S]sulfate when galactose is substituted for glucose in the medium; galactose-1-phosphate uridyltransferase-deficient cells incorporate 65.5 percent less. In addition to incorporating less [35S]sulfate, the uridyltransferase-deficient cells showed significant accumulation of intracellular galactose-1-phosphate within 4 hours after galactose exposure. Under the same conditions, no difference in [3H]uridine incorporation was observed. This metabolic alteration, occurring in response to galactose exposure, may be related to the pathophysiology of classical galactosemia.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

472754

Citation

Tedesco, T A., and K L. Miller. "Galactosemia: Alterations in Sulfate Metabolism Secondary to Galactose-1-phosphate Uridyltransferase Deficiency." Science (New York, N.Y.), vol. 205, no. 4413, 1979, pp. 1395-7.
Tedesco TA, Miller KL. Galactosemia: alterations in sulfate metabolism secondary to galactose-1-phosphate uridyltransferase deficiency. Science. 1979;205(4413):1395-7.
Tedesco, T. A., & Miller, K. L. (1979). Galactosemia: alterations in sulfate metabolism secondary to galactose-1-phosphate uridyltransferase deficiency. Science (New York, N.Y.), 205(4413), 1395-7.
Tedesco TA, Miller KL. Galactosemia: Alterations in Sulfate Metabolism Secondary to Galactose-1-phosphate Uridyltransferase Deficiency. Science. 1979 Sep 28;205(4413):1395-7. PubMed PMID: 472754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Galactosemia: alterations in sulfate metabolism secondary to galactose-1-phosphate uridyltransferase deficiency. AU - Tedesco,T A, AU - Miller,K L, PY - 1979/9/28/pubmed PY - 1979/9/28/medline PY - 1979/9/28/entrez SP - 1395 EP - 7 JF - Science (New York, N.Y.) JO - Science VL - 205 IS - 4413 N2 - Cultures of nonmutant as well as galactokinase-deficient fibroblasts incorporate 20 percent more [35S]sulfate when galactose is substituted for glucose in the medium; galactose-1-phosphate uridyltransferase-deficient cells incorporate 65.5 percent less. In addition to incorporating less [35S]sulfate, the uridyltransferase-deficient cells showed significant accumulation of intracellular galactose-1-phosphate within 4 hours after galactose exposure. Under the same conditions, no difference in [3H]uridine incorporation was observed. This metabolic alteration, occurring in response to galactose exposure, may be related to the pathophysiology of classical galactosemia. SN - 0036-8075 UR - https://www.unboundmedicine.com/medline/citation/472754/Galactosemia:_alterations_in_sulfate_metabolism_secondary_to_galactose_1_phosphate_uridyltransferase_deficiency_ L2 - https:///www.science.org/doi/10.1126/science.472754?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -