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Comparative pharmacology of Delta9-tetrahydrocannabinol and its metabolite, 11-OH-Delta9-tetrahydrocannabinol.
J Clin Invest. 1973 Oct; 52(10):2411-7.JCI

Abstract

A comparison of the psychologic and physiologic effects of intravenously administered Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and 11-hydroxy-Delta(9)-tetrahydrocannabinol (11-OH-Delta(9)-THC) was carried out in nine casual marihuana smokers. A marked tachycardia and psychologic "high" occurred within 3-5 min after the i.v. administration of 11-OH-Delta(9)-THC (1 mg) to all subjects. In contrast, the peak psychologic "high" was delayed 10-20 min after the i.v. administration of Delta(9)-THC (1 mg). There was some individual variation in response among subjects. Psychologic effects correlated well with plasma levels of unchanged [(3)H]11-OH-Delta(9)-THC. About 75% of the administered radioactive dose was excreted in urine (25%) and feces (50%) after [(3)H]11-OH-Delta(9)-THC administration. The disposition, excretion, and metabolism of [(3)H]11-OH-Delta(9)-THC appear to be similar to that previously reported after [(14)C]Delta(9)-THC administration. These findings, in conjunction with the marked psychologic high seen after 11-OH-Delta(9)-THC, suggest that in man, Delta(9)-THC, the active constituent in marihuana, is converted to 11-OH-Delta(9)-THC, which is in part responsible for the psychologic effects.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

4729039

Citation

Lemberger, L, et al. "Comparative Pharmacology of Delta9-tetrahydrocannabinol and Its Metabolite, 11-OH-Delta9-tetrahydrocannabinol." The Journal of Clinical Investigation, vol. 52, no. 10, 1973, pp. 2411-7.
Lemberger L, Martz R, Rodda B, et al. Comparative pharmacology of Delta9-tetrahydrocannabinol and its metabolite, 11-OH-Delta9-tetrahydrocannabinol. J Clin Invest. 1973;52(10):2411-7.
Lemberger, L., Martz, R., Rodda, B., Forney, R., & Rowe, H. (1973). Comparative pharmacology of Delta9-tetrahydrocannabinol and its metabolite, 11-OH-Delta9-tetrahydrocannabinol. The Journal of Clinical Investigation, 52(10), 2411-7.
Lemberger L, et al. Comparative Pharmacology of Delta9-tetrahydrocannabinol and Its Metabolite, 11-OH-Delta9-tetrahydrocannabinol. J Clin Invest. 1973;52(10):2411-7. PubMed PMID: 4729039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative pharmacology of Delta9-tetrahydrocannabinol and its metabolite, 11-OH-Delta9-tetrahydrocannabinol. AU - Lemberger,L, AU - Martz,R, AU - Rodda,B, AU - Forney,R, AU - Rowe,H, PY - 1973/10/1/pubmed PY - 1973/10/1/medline PY - 1973/10/1/entrez SP - 2411 EP - 7 JF - The Journal of clinical investigation JO - J Clin Invest VL - 52 IS - 10 N2 - A comparison of the psychologic and physiologic effects of intravenously administered Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and 11-hydroxy-Delta(9)-tetrahydrocannabinol (11-OH-Delta(9)-THC) was carried out in nine casual marihuana smokers. A marked tachycardia and psychologic "high" occurred within 3-5 min after the i.v. administration of 11-OH-Delta(9)-THC (1 mg) to all subjects. In contrast, the peak psychologic "high" was delayed 10-20 min after the i.v. administration of Delta(9)-THC (1 mg). There was some individual variation in response among subjects. Psychologic effects correlated well with plasma levels of unchanged [(3)H]11-OH-Delta(9)-THC. About 75% of the administered radioactive dose was excreted in urine (25%) and feces (50%) after [(3)H]11-OH-Delta(9)-THC administration. The disposition, excretion, and metabolism of [(3)H]11-OH-Delta(9)-THC appear to be similar to that previously reported after [(14)C]Delta(9)-THC administration. These findings, in conjunction with the marked psychologic high seen after 11-OH-Delta(9)-THC, suggest that in man, Delta(9)-THC, the active constituent in marihuana, is converted to 11-OH-Delta(9)-THC, which is in part responsible for the psychologic effects. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/4729039/Comparative_pharmacology_of_Delta9_tetrahydrocannabinol_and_its_metabolite_11_OH_Delta9_tetrahydrocannabinol_ L2 - https://doi.org/10.1172/JCI107431 DB - PRIME DP - Unbound Medicine ER -