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Neural antigens and induction of myelination inhibition factor.
J Immunol. 1975 Feb; 114(2 Pt 1):630-4.JI

Abstract

Rabbits were sensitized or immunized with a variety of central nervous system antigens, including bovine spinal cord, bovine, monkey, human, guinea pig, rabbit and rat S myelin basic proteins, and a polypeptide derived from guinea pig basic protein. The animals were observed for development of experimental allergic encephalomyelitis, and their sera were collected at varying intervals after inoculation and evaluated for presence of precipitating anti-basic protein antibody and for their ability to inhibit myelin formation in cerebellar tissue cultures. The resulting complete dissociation between development of experimental allergic encephalomyelitis, the presence of anti-basic protein antibody and the occurrence of myelination inhibition factor suggests that myelination inhibition factor is not involved in the pathogenesis of experimental allergic encephalomyelitis, and argues against a role for anti-basic protein antibody as an antimyelin factor in vitro.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

47359

Citation

Seil, F J., et al. "Neural Antigens and Induction of Myelination Inhibition Factor." Journal of Immunology (Baltimore, Md. : 1950), vol. 114, no. 2 Pt 1, 1975, pp. 630-4.
Seil FJ, Kies MW, Bacon M. Neural antigens and induction of myelination inhibition factor. J Immunol. 1975;114(2 Pt 1):630-4.
Seil, F. J., Kies, M. W., & Bacon, M. (1975). Neural antigens and induction of myelination inhibition factor. Journal of Immunology (Baltimore, Md. : 1950), 114(2 Pt 1), 630-4.
Seil FJ, Kies MW, Bacon M. Neural Antigens and Induction of Myelination Inhibition Factor. J Immunol. 1975;114(2 Pt 1):630-4. PubMed PMID: 47359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neural antigens and induction of myelination inhibition factor. AU - Seil,F J, AU - Kies,M W, AU - Bacon,M, PY - 1975/2/1/pubmed PY - 1975/2/1/medline PY - 1975/2/1/entrez SP - 630 EP - 4 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 114 IS - 2 Pt 1 N2 - Rabbits were sensitized or immunized with a variety of central nervous system antigens, including bovine spinal cord, bovine, monkey, human, guinea pig, rabbit and rat S myelin basic proteins, and a polypeptide derived from guinea pig basic protein. The animals were observed for development of experimental allergic encephalomyelitis, and their sera were collected at varying intervals after inoculation and evaluated for presence of precipitating anti-basic protein antibody and for their ability to inhibit myelin formation in cerebellar tissue cultures. The resulting complete dissociation between development of experimental allergic encephalomyelitis, the presence of anti-basic protein antibody and the occurrence of myelination inhibition factor suggests that myelination inhibition factor is not involved in the pathogenesis of experimental allergic encephalomyelitis, and argues against a role for anti-basic protein antibody as an antimyelin factor in vitro. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/47359/Neural_antigens_and_induction_of_myelination_inhibition_factor_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=47359 DB - PRIME DP - Unbound Medicine ER -