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Zollinger-Ellison syndrome unresponsive to cimetidine.
Am J Gastroenterol. 1979 Aug; 72(2):168-70.AJ

Abstract

A patient with Zollinger-Ellison syndrome appeared initially to respond to cimetidine with a reduction in gastric acid secretion. Symptoms immediately improved but after three days recurred with increasing severity. Intravenous cimetidine had only a short-lived and partial inhibitory effect on the rate of acid production and because of continuing pain and progressive bleeding from his duodenal ulcer, total gastrectomy was performed. Evidence of the effect of atropine and of oral and intravenous cimetidine is presented. Despite recent optimism, cimetidine is not always adequate treatment for Zollinger-Ellison syndrome.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

474557

Citation

Groarke, J F., et al. "Zollinger-Ellison Syndrome Unresponsive to Cimetidine." The American Journal of Gastroenterology, vol. 72, no. 2, 1979, pp. 168-70.
Groarke JF, Haggstrom GD, Halpern NB, et al. Zollinger-Ellison syndrome unresponsive to cimetidine. Am J Gastroenterol. 1979;72(2):168-70.
Groarke, J. F., Haggstrom, G. D., Halpern, N. B., & Hirschowitz, B. I. (1979). Zollinger-Ellison syndrome unresponsive to cimetidine. The American Journal of Gastroenterology, 72(2), 168-70.
Groarke JF, et al. Zollinger-Ellison Syndrome Unresponsive to Cimetidine. Am J Gastroenterol. 1979;72(2):168-70. PubMed PMID: 474557.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zollinger-Ellison syndrome unresponsive to cimetidine. AU - Groarke,J F, AU - Haggstrom,G D, AU - Halpern,N B, AU - Hirschowitz,B I, PY - 1979/8/1/pubmed PY - 1979/8/1/medline PY - 1979/8/1/entrez SP - 168 EP - 70 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 72 IS - 2 N2 - A patient with Zollinger-Ellison syndrome appeared initially to respond to cimetidine with a reduction in gastric acid secretion. Symptoms immediately improved but after three days recurred with increasing severity. Intravenous cimetidine had only a short-lived and partial inhibitory effect on the rate of acid production and because of continuing pain and progressive bleeding from his duodenal ulcer, total gastrectomy was performed. Evidence of the effect of atropine and of oral and intravenous cimetidine is presented. Despite recent optimism, cimetidine is not always adequate treatment for Zollinger-Ellison syndrome. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/474557/Zollinger_Ellison_syndrome_unresponsive_to_cimetidine_ L2 - http://www.diseaseinfosearch.org/result/7600 DB - PRIME DP - Unbound Medicine ER -