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Chronic idiopathic intestinal pseudo-obstruction with malabsorption, a scleroderma-like disorder.
Can Med Assoc J. 1973 Dec 15; 109(12):1222-7.CM

Abstract

A case of intestinal pseudo-obstruction in a 76-year-old man who presented with a six-year history of intermittent vomiting and abdominal pain and a 1(1/2)-year history of diarrhea is described. Investigation demonstrated aperistalsis of the lower esophagus and an unresponsive atonic small intestine. Marked malabsorption was present and appeared due to intestinal bacterial overgrowth consequent to the hypomotility. Autonomic nervous system testing failed to reveal any definite abnormality. Although this disorder is markedly similar to scleroderma involving the gastrointestinal tract, there was only minimal fibrosis of the bowel musculature evident at autopsy and the neural components appeared to be intact. These findings suggest that the basic disorder may be one of smooth muscle dysfunction. Other known causes of pseudo-obstruction could not be demonstrated.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

4758595

Citation

Lukie, B E., and M G. Sanders. "Chronic Idiopathic Intestinal Pseudo-obstruction With Malabsorption, a Scleroderma-like Disorder." Canadian Medical Association Journal, vol. 109, no. 12, 1973, pp. 1222-7.
Lukie BE, Sanders MG. Chronic idiopathic intestinal pseudo-obstruction with malabsorption, a scleroderma-like disorder. Can Med Assoc J. 1973;109(12):1222-7.
Lukie, B. E., & Sanders, M. G. (1973). Chronic idiopathic intestinal pseudo-obstruction with malabsorption, a scleroderma-like disorder. Canadian Medical Association Journal, 109(12), 1222-7.
Lukie BE, Sanders MG. Chronic Idiopathic Intestinal Pseudo-obstruction With Malabsorption, a Scleroderma-like Disorder. Can Med Assoc J. 1973 Dec 15;109(12):1222-7. PubMed PMID: 4758595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic idiopathic intestinal pseudo-obstruction with malabsorption, a scleroderma-like disorder. AU - Lukie,B E, AU - Sanders,M G, PY - 1973/12/15/pubmed PY - 1973/12/15/medline PY - 1973/12/15/entrez SP - 1222 EP - 7 JF - Canadian Medical Association journal JO - Can Med Assoc J VL - 109 IS - 12 N2 - A case of intestinal pseudo-obstruction in a 76-year-old man who presented with a six-year history of intermittent vomiting and abdominal pain and a 1(1/2)-year history of diarrhea is described. Investigation demonstrated aperistalsis of the lower esophagus and an unresponsive atonic small intestine. Marked malabsorption was present and appeared due to intestinal bacterial overgrowth consequent to the hypomotility. Autonomic nervous system testing failed to reveal any definite abnormality. Although this disorder is markedly similar to scleroderma involving the gastrointestinal tract, there was only minimal fibrosis of the bowel musculature evident at autopsy and the neural components appeared to be intact. These findings suggest that the basic disorder may be one of smooth muscle dysfunction. Other known causes of pseudo-obstruction could not be demonstrated. SN - 0008-4409 UR - https://www.unboundmedicine.com/medline/citation/4758595/Chronic_idiopathic_intestinal_pseudo_obstruction_with_malabsorption_a_scleroderma_like_disorder_ DB - PRIME DP - Unbound Medicine ER -