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Identification of urinary metabolites of flavanone in the rat.
Biomed Mass Spectrom. 1979 May; 6(5):212-20.BM

Abstract

The urinary metabolites of flavanone in the rate were investigated using a gas chromatographic mass spectrometric method employing an OV-1 capillary column. Forty-three metabolites were detected and the most prominent of these were identified. The most common metabolic reactions were reduction of the keto group and hydroxylation at the 3- or 6-positions. Little hydroxylation occurred in ring B. The major metabolites were flavan-4 alpha-ol, trans-3-hydroxyflavan-4 beta-ol, 6-hydroxyflavanone and 6-hydroxyflavan-4 beta-ol. Gas chromatography analysis of underivatized flavanone metabolites, especially with stainless steel columns, results in the formation of dehydrated products including flavone, flav-3-ene and flavanone itself.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

476285

Citation

Buset, H, and R R. Scheline. "Identification of Urinary Metabolites of Flavanone in the Rat." Biomedical Mass Spectrometry, vol. 6, no. 5, 1979, pp. 212-20.
Buset H, Scheline RR. Identification of urinary metabolites of flavanone in the rat. Biomed Mass Spectrom. 1979;6(5):212-20.
Buset, H., & Scheline, R. R. (1979). Identification of urinary metabolites of flavanone in the rat. Biomedical Mass Spectrometry, 6(5), 212-20.
Buset H, Scheline RR. Identification of Urinary Metabolites of Flavanone in the Rat. Biomed Mass Spectrom. 1979;6(5):212-20. PubMed PMID: 476285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of urinary metabolites of flavanone in the rat. AU - Buset,H, AU - Scheline,R R, PY - 1979/5/1/pubmed PY - 1979/5/1/medline PY - 1979/5/1/entrez SP - 212 EP - 20 JF - Biomedical mass spectrometry JO - Biomed. Mass Spectrom. VL - 6 IS - 5 N2 - The urinary metabolites of flavanone in the rate were investigated using a gas chromatographic mass spectrometric method employing an OV-1 capillary column. Forty-three metabolites were detected and the most prominent of these were identified. The most common metabolic reactions were reduction of the keto group and hydroxylation at the 3- or 6-positions. Little hydroxylation occurred in ring B. The major metabolites were flavan-4 alpha-ol, trans-3-hydroxyflavan-4 beta-ol, 6-hydroxyflavanone and 6-hydroxyflavan-4 beta-ol. Gas chromatography analysis of underivatized flavanone metabolites, especially with stainless steel columns, results in the formation of dehydrated products including flavone, flav-3-ene and flavanone itself. SN - 0306-042X UR - https://www.unboundmedicine.com/medline/citation/476285/Identification_of_urinary_metabolites_of_flavanone_in_the_rat_ DB - PRIME DP - Unbound Medicine ER -
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