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Non-protein-bound oestrogens in plasma and urinary excretion of unconjugated oestrogens in men.
Clin Endocrinol (Oxf) 1979; 10(4):329-41CE

Abstract

Unconjugated oestrone and unconjugated oestradiol-17 beta were measured in 24 h urine specimens from twenty normal men. The concentrations of non-protein-bound oestrone and non-protein-bound oestradiol-17 beta, in samples of blood obtained from these subjects during the time in which the urine was collected, were measured by equilibrium dialysis (using a correction for plasma dilution). The mean excretion of unconjugated oestrone (0.44+/- 0.36 nmol/24 h, mean +/- SD) was significantly greater (Pless than 0.01) than that of unconjugated oestradiol-17 beta (0.20 +/- 0.13 nmol/24 h). The concentrations of non-protein-bound oestrone and non-protein-bound oestradiol-17 beta in plasma were 5.52 +/- 2.69pmol/1 and 2.42 +/- 0.73 pmol/1, respectively. There was no correlation between the quantity of unconjugated oestrone excreted and the concentration of non-protein-bound oestrone in plasma (r=0.27) nor between the quantity of unconjugated oestradiol-17 beta in the urine and the concentration of non-protein-bound oestradiol-17 beta in plasma (r=0.05). Therefore in normal men, estimation of unconjugated oestrone or oestradiol-17 beta in urine provides no guide to the concentration of the corresponding non-protein-bound oestrogen in plasma.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

476969

Citation

Speight, A C., et al. "Non-protein-bound Oestrogens in Plasma and Urinary Excretion of Unconjugated Oestrogens in Men." Clinical Endocrinology, vol. 10, no. 4, 1979, pp. 329-41.
Speight AC, Hancock KW, Oakey RE. Non-protein-bound oestrogens in plasma and urinary excretion of unconjugated oestrogens in men. Clin Endocrinol (Oxf). 1979;10(4):329-41.
Speight, A. C., Hancock, K. W., & Oakey, R. E. (1979). Non-protein-bound oestrogens in plasma and urinary excretion of unconjugated oestrogens in men. Clinical Endocrinology, 10(4), pp. 329-41.
Speight AC, Hancock KW, Oakey RE. Non-protein-bound Oestrogens in Plasma and Urinary Excretion of Unconjugated Oestrogens in Men. Clin Endocrinol (Oxf). 1979;10(4):329-41. PubMed PMID: 476969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-protein-bound oestrogens in plasma and urinary excretion of unconjugated oestrogens in men. AU - Speight,A C, AU - Hancock,K W, AU - Oakey,R E, PY - 1979/4/1/pubmed PY - 1979/4/1/medline PY - 1979/4/1/entrez SP - 329 EP - 41 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 10 IS - 4 N2 - Unconjugated oestrone and unconjugated oestradiol-17 beta were measured in 24 h urine specimens from twenty normal men. The concentrations of non-protein-bound oestrone and non-protein-bound oestradiol-17 beta, in samples of blood obtained from these subjects during the time in which the urine was collected, were measured by equilibrium dialysis (using a correction for plasma dilution). The mean excretion of unconjugated oestrone (0.44+/- 0.36 nmol/24 h, mean +/- SD) was significantly greater (Pless than 0.01) than that of unconjugated oestradiol-17 beta (0.20 +/- 0.13 nmol/24 h). The concentrations of non-protein-bound oestrone and non-protein-bound oestradiol-17 beta in plasma were 5.52 +/- 2.69pmol/1 and 2.42 +/- 0.73 pmol/1, respectively. There was no correlation between the quantity of unconjugated oestrone excreted and the concentration of non-protein-bound oestrone in plasma (r=0.27) nor between the quantity of unconjugated oestradiol-17 beta in the urine and the concentration of non-protein-bound oestradiol-17 beta in plasma (r=0.05). Therefore in normal men, estimation of unconjugated oestrone or oestradiol-17 beta in urine provides no guide to the concentration of the corresponding non-protein-bound oestrogen in plasma. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/476969/Non_protein_bound_oestrogens_in_plasma_and_urinary_excretion_of_unconjugated_oestrogens_in_men_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0300-0664&date=1979&volume=10&issue=4&spage=329 DB - PRIME DP - Unbound Medicine ER -