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Kayser-Fleischer ring and associated cataract in Wilson's disease.
Am J Ophthalmol 1975; 79(3):479-88AJ

Abstract

A 22-year-old woman with hepatolenticular degeneration, or Wilson's disease, was note clinically to have Kayser-Fleischer rings and associated cataracts. Histopathologic, histochemical, and electron microscopic study of the cornea showed deposition of copper in the peripheral Descemet's membrane, with excessive accumulation in Hassall-Henel warts. Copper deposits were also noted in the anterior and posterior lens capsule without the presence of degenerative changes in the epithelial or cortical cells of the lens. We propose that cellular activity is required for the depostion of copper material into the thick basement membranes of the cornea and lens, in contrast to the concept of simple diffusion.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

47714

Citation

Tso, M O., et al. "Kayser-Fleischer Ring and Associated Cataract in Wilson's Disease." American Journal of Ophthalmology, vol. 79, no. 3, 1975, pp. 479-88.
Tso MO, Fine BS, Thorpe HE. Kayser-Fleischer ring and associated cataract in Wilson's disease. Am J Ophthalmol. 1975;79(3):479-88.
Tso, M. O., Fine, B. S., & Thorpe, H. E. (1975). Kayser-Fleischer ring and associated cataract in Wilson's disease. American Journal of Ophthalmology, 79(3), pp. 479-88.
Tso MO, Fine BS, Thorpe HE. Kayser-Fleischer Ring and Associated Cataract in Wilson's Disease. Am J Ophthalmol. 1975;79(3):479-88. PubMed PMID: 47714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kayser-Fleischer ring and associated cataract in Wilson's disease. AU - Tso,M O, AU - Fine,B S, AU - Thorpe,H E, PY - 1975/3/1/pubmed PY - 1975/3/1/medline PY - 1975/3/1/entrez SP - 479 EP - 88 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 79 IS - 3 N2 - A 22-year-old woman with hepatolenticular degeneration, or Wilson's disease, was note clinically to have Kayser-Fleischer rings and associated cataracts. Histopathologic, histochemical, and electron microscopic study of the cornea showed deposition of copper in the peripheral Descemet's membrane, with excessive accumulation in Hassall-Henel warts. Copper deposits were also noted in the anterior and posterior lens capsule without the presence of degenerative changes in the epithelial or cortical cells of the lens. We propose that cellular activity is required for the depostion of copper material into the thick basement membranes of the cornea and lens, in contrast to the concept of simple diffusion. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/47714/Kayser_Fleischer_ring_and_associated_cataract_in_Wilson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9394(75)90625-X DB - PRIME DP - Unbound Medicine ER -