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Oral glucose in cirrhotics. Effects on plasma aminoacid patterns and the role of insulin and glucagon.
Diabete Metab. 1979 Jun; 5(2):135-9.DM

Abstract

Changes in the plasma aminoacid (AA) profile present in hepatic encephalopathy were related to a catabolic state characterized by a reduced insulin/glucagon molar ratio (IRI/IRG). Oral glucose is able to suppress the hyperglucagonemia and further to increase the elevated insulin levels of cirrhotics leading to a rise of IRI/IRG. We evaluated the plasma AAs in ten controls and twelve cirrhotics following the ingestion of oral glucose. At 180 min we demonstrated a similar fall (about 35%) of plasma AAs both in cirrhotics and in controls, with the exception of free tryptophan, which fell more markedly in cirrhotics (about 60%), possibly secondary to the fall in plasma free fatty acids. After the oral glucose load, the levels of aromatic AAs and free tryptophan, as well as the molar ratio free tryptophan/branched-chain + aromatic AAs returned to normal in cirrhotics. High levels of both aromatic AAs and free tryptophan have been implicated in the pathogenesis of hepatic coma. Our data support the hypothesis that the administration of oral glucose might be relevant in the management of cirrhotic patients with hepatic encephalopathy, possibly improving their mental state.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

478083

Citation

Marchesini, G, et al. "Oral Glucose in Cirrhotics. Effects On Plasma Aminoacid Patterns and the Role of Insulin and Glucagon." Diabete & Metabolisme, vol. 5, no. 2, 1979, pp. 135-9.
Marchesini G, Forlani G, Angiolini A, et al. Oral glucose in cirrhotics. Effects on plasma aminoacid patterns and the role of insulin and glucagon. Diabete Metab. 1979;5(2):135-9.
Marchesini, G., Forlani, G., Angiolini, A., Zoli, M., Scolari, M. P., Bianchi, F. B., & Pisi, E. (1979). Oral glucose in cirrhotics. Effects on plasma aminoacid patterns and the role of insulin and glucagon. Diabete & Metabolisme, 5(2), 135-9.
Marchesini G, et al. Oral Glucose in Cirrhotics. Effects On Plasma Aminoacid Patterns and the Role of Insulin and Glucagon. Diabete Metab. 1979;5(2):135-9. PubMed PMID: 478083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral glucose in cirrhotics. Effects on plasma aminoacid patterns and the role of insulin and glucagon. AU - Marchesini,G, AU - Forlani,G, AU - Angiolini,A, AU - Zoli,M, AU - Scolari,M P, AU - Bianchi,F B, AU - Pisi,E, PY - 1979/6/1/pubmed PY - 2000/3/11/medline PY - 1979/6/1/entrez SP - 135 EP - 9 JF - Diabete & metabolisme JO - Diabete Metab VL - 5 IS - 2 N2 - Changes in the plasma aminoacid (AA) profile present in hepatic encephalopathy were related to a catabolic state characterized by a reduced insulin/glucagon molar ratio (IRI/IRG). Oral glucose is able to suppress the hyperglucagonemia and further to increase the elevated insulin levels of cirrhotics leading to a rise of IRI/IRG. We evaluated the plasma AAs in ten controls and twelve cirrhotics following the ingestion of oral glucose. At 180 min we demonstrated a similar fall (about 35%) of plasma AAs both in cirrhotics and in controls, with the exception of free tryptophan, which fell more markedly in cirrhotics (about 60%), possibly secondary to the fall in plasma free fatty acids. After the oral glucose load, the levels of aromatic AAs and free tryptophan, as well as the molar ratio free tryptophan/branched-chain + aromatic AAs returned to normal in cirrhotics. High levels of both aromatic AAs and free tryptophan have been implicated in the pathogenesis of hepatic coma. Our data support the hypothesis that the administration of oral glucose might be relevant in the management of cirrhotic patients with hepatic encephalopathy, possibly improving their mental state. SN - 0338-1684 UR - https://www.unboundmedicine.com/medline/citation/478083/Oral_glucose_in_cirrhotics__Effects_on_plasma_aminoacid_patterns_and_the_role_of_insulin_and_glucagon_ DB - PRIME DP - Unbound Medicine ER -