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Food iron absorption in man. Applications of the two-pool extrinsic tag method to measure heme and nonheme iron absorption from the whole diet.
J Clin Invest. 1974 Jan; 53(1):247-55.JCI

Abstract

A new radioisotope method to measure iron absorption from the whole diet was used in this study. The method is based on the concept that food iron is absorbed from two pools, the heme iron pool and the nonheme iron pool, which can be especially labeled with two radioiron isotopes given as hemoglobin and as an iron salt. The purpose of this study was to test the accuracy of this two-pool extrinsic tag method. The meals served were composed as an average of 6 wk consumption in the present material of 32 young enlisted men. The mean and total heme and nonheme iron absorption in all the 32 young men was 1.01+/-0.11. This figure agrees well with the mean daily losses expected for this group of subjects (1.0 mg). The conclusion can therefore be made that there are no major systematic errors of the present method to measure the total iron absorption from a mixed diet. In one series a comparison was made of the absorption of heme and nonheme iron from the meals. A significant correlation between the absorption of the two kinds of iron was found. However, a much greater fraction of the heme iron was absorbed (37%) than of the nonheme iron (5%). The absorption both from breakfast and lunch was in two series found to give a good prediction of the total daily nonheme iron absorption. One series was designed to compare the effect of two levels of iron fortification. There was a significant increase in iron absorption when the level of iron fortification of the meals was increased.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

4808639

Citation

Björn-Rasmussen, E, et al. "Food Iron Absorption in Man. Applications of the Two-pool Extrinsic Tag Method to Measure Heme and Nonheme Iron Absorption From the Whole Diet." The Journal of Clinical Investigation, vol. 53, no. 1, 1974, pp. 247-55.
Björn-Rasmussen E, Hallberg L, Isaksson B, et al. Food iron absorption in man. Applications of the two-pool extrinsic tag method to measure heme and nonheme iron absorption from the whole diet. J Clin Invest. 1974;53(1):247-55.
Björn-Rasmussen, E., Hallberg, L., Isaksson, B., & Arvidsson, B. (1974). Food iron absorption in man. Applications of the two-pool extrinsic tag method to measure heme and nonheme iron absorption from the whole diet. The Journal of Clinical Investigation, 53(1), 247-55.
Björn-Rasmussen E, et al. Food Iron Absorption in Man. Applications of the Two-pool Extrinsic Tag Method to Measure Heme and Nonheme Iron Absorption From the Whole Diet. J Clin Invest. 1974;53(1):247-55. PubMed PMID: 4808639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Food iron absorption in man. Applications of the two-pool extrinsic tag method to measure heme and nonheme iron absorption from the whole diet. AU - Björn-Rasmussen,E, AU - Hallberg,L, AU - Isaksson,B, AU - Arvidsson,B, PY - 1974/1/1/pubmed PY - 1974/1/1/medline PY - 1974/1/1/entrez SP - 247 EP - 55 JF - The Journal of clinical investigation JO - J Clin Invest VL - 53 IS - 1 N2 - A new radioisotope method to measure iron absorption from the whole diet was used in this study. The method is based on the concept that food iron is absorbed from two pools, the heme iron pool and the nonheme iron pool, which can be especially labeled with two radioiron isotopes given as hemoglobin and as an iron salt. The purpose of this study was to test the accuracy of this two-pool extrinsic tag method. The meals served were composed as an average of 6 wk consumption in the present material of 32 young enlisted men. The mean and total heme and nonheme iron absorption in all the 32 young men was 1.01+/-0.11. This figure agrees well with the mean daily losses expected for this group of subjects (1.0 mg). The conclusion can therefore be made that there are no major systematic errors of the present method to measure the total iron absorption from a mixed diet. In one series a comparison was made of the absorption of heme and nonheme iron from the meals. A significant correlation between the absorption of the two kinds of iron was found. However, a much greater fraction of the heme iron was absorbed (37%) than of the nonheme iron (5%). The absorption both from breakfast and lunch was in two series found to give a good prediction of the total daily nonheme iron absorption. One series was designed to compare the effect of two levels of iron fortification. There was a significant increase in iron absorption when the level of iron fortification of the meals was increased. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/4808639/Food_iron_absorption_in_man__Applications_of_the_two_pool_extrinsic_tag_method_to_measure_heme_and_nonheme_iron_absorption_from_the_whole_diet_ L2 - https://doi.org/10.1172/JCI107545 DB - PRIME DP - Unbound Medicine ER -