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The development of an artificial beta cell system and its validation in depancreatized dogs: the physiological restoration of blood glucose homeostasis.
Med Prog Technol. 1979 Jun 15; 6(3):99-108.MP

Abstract

An instrument for the control of blood glucose in a closed-loop fashion has been developed. This artificial beta cell consists of 4 subunits: a Glucose Monitor, a Microcomputer, an Insulin Infusion Pump and a Printer. Its internal control algorithm was derived from the modeled dynamics of glucose-induced insulin secretion, and includes the effects of both the proportional and derivative actions of blood glucose concentration, and is expressed as: IIR = Kp . BG + Kd . deltaBG + Kc, where IIR is insulin infusion rate, BG and deltaBG are blood glucose concentration and rate of change in glycemia, respectively. Kp and Kd are individual coefficients and Kc is a constant of basal insulin secretion. The performance of this system was studied with various kinds of glucose challenges on anaesthetized depancreatized dogs. Its notable characteristics were: 1) the insulin infusion rate was such as to maintain physiological insulin levels, and 2) dextrose or glucagon infusions were not required.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

481366

Citation

Goriya, Y, et al. "The Development of an Artificial Beta Cell System and Its Validation in Depancreatized Dogs: the Physiological Restoration of Blood Glucose Homeostasis." Medical Progress Through Technology, vol. 6, no. 3, 1979, pp. 99-108.
Goriya Y, Kawamori R, Shichiri M, et al. The development of an artificial beta cell system and its validation in depancreatized dogs: the physiological restoration of blood glucose homeostasis. Med Prog Technol. 1979;6(3):99-108.
Goriya, Y., Kawamori, R., Shichiri, M., & Abe, H. (1979). The development of an artificial beta cell system and its validation in depancreatized dogs: the physiological restoration of blood glucose homeostasis. Medical Progress Through Technology, 6(3), 99-108.
Goriya Y, et al. The Development of an Artificial Beta Cell System and Its Validation in Depancreatized Dogs: the Physiological Restoration of Blood Glucose Homeostasis. Med Prog Technol. 1979 Jun 15;6(3):99-108. PubMed PMID: 481366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The development of an artificial beta cell system and its validation in depancreatized dogs: the physiological restoration of blood glucose homeostasis. AU - Goriya,Y, AU - Kawamori,R, AU - Shichiri,M, AU - Abe,H, PY - 1979/6/15/pubmed PY - 1979/6/15/medline PY - 1979/6/15/entrez SP - 99 EP - 108 JF - Medical progress through technology JO - Med Prog Technol VL - 6 IS - 3 N2 - An instrument for the control of blood glucose in a closed-loop fashion has been developed. This artificial beta cell consists of 4 subunits: a Glucose Monitor, a Microcomputer, an Insulin Infusion Pump and a Printer. Its internal control algorithm was derived from the modeled dynamics of glucose-induced insulin secretion, and includes the effects of both the proportional and derivative actions of blood glucose concentration, and is expressed as: IIR = Kp . BG + Kd . deltaBG + Kc, where IIR is insulin infusion rate, BG and deltaBG are blood glucose concentration and rate of change in glycemia, respectively. Kp and Kd are individual coefficients and Kc is a constant of basal insulin secretion. The performance of this system was studied with various kinds of glucose challenges on anaesthetized depancreatized dogs. Its notable characteristics were: 1) the insulin infusion rate was such as to maintain physiological insulin levels, and 2) dextrose or glucagon infusions were not required. SN - 0047-6552 UR - https://www.unboundmedicine.com/medline/citation/481366/The_development_of_an_artificial_beta_cell_system_and_its_validation_in_depancreatized_dogs:_the_physiological_restoration_of_blood_glucose_homeostasis_ L2 - https://medlineplus.gov/bloodsugar.html DB - PRIME DP - Unbound Medicine ER -