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Leg ulceration in sickle cell disease in Nigeria.
Trop Geogr Med 1979; 31(1):87-91TG

Abstract

Leg ulceration was found in only 14 of 834 (1.7%) sickle cell patients seen in a Lagos Hospital. Ulcers were seen only in patients above the age of 12 years in whom the prevalence was 5.4%. Affected males outnumbered females 6 to 1. The aetiology was traumatic in 12 patients, spontaneous in three and due to furuncle in one. The commonest sites were around the ankles. Ulceration was not commoner in patients with low socioeconomic status. The simplest forms of aseptic treatment resulted in as variable a healing time as more complex forms of treatment, but a high recurrence rate of ulceration (71.4%) was the major problem. There remains no acceptable reason for the lower prevalence of leg ulceration in Africans with sickle cell disease, but the role of zinc in susceptibility to the ulcers deserves further investigation.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

483376

Citation

Akinyanju, O, and I Akinsete. "Leg Ulceration in Sickle Cell Disease in Nigeria." Tropical and Geographical Medicine, vol. 31, no. 1, 1979, pp. 87-91.
Akinyanju O, Akinsete I. Leg ulceration in sickle cell disease in Nigeria. Trop Geogr Med. 1979;31(1):87-91.
Akinyanju, O., & Akinsete, I. (1979). Leg ulceration in sickle cell disease in Nigeria. Tropical and Geographical Medicine, 31(1), pp. 87-91.
Akinyanju O, Akinsete I. Leg Ulceration in Sickle Cell Disease in Nigeria. Trop Geogr Med. 1979;31(1):87-91. PubMed PMID: 483376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leg ulceration in sickle cell disease in Nigeria. AU - Akinyanju,O, AU - Akinsete,I, PY - 1979/3/1/pubmed PY - 1979/3/1/medline PY - 1979/3/1/entrez SP - 87 EP - 91 JF - Tropical and geographical medicine JO - Trop Geogr Med VL - 31 IS - 1 N2 - Leg ulceration was found in only 14 of 834 (1.7%) sickle cell patients seen in a Lagos Hospital. Ulcers were seen only in patients above the age of 12 years in whom the prevalence was 5.4%. Affected males outnumbered females 6 to 1. The aetiology was traumatic in 12 patients, spontaneous in three and due to furuncle in one. The commonest sites were around the ankles. Ulceration was not commoner in patients with low socioeconomic status. The simplest forms of aseptic treatment resulted in as variable a healing time as more complex forms of treatment, but a high recurrence rate of ulceration (71.4%) was the major problem. There remains no acceptable reason for the lower prevalence of leg ulceration in Africans with sickle cell disease, but the role of zinc in susceptibility to the ulcers deserves further investigation. SN - 0041-3232 UR - https://www.unboundmedicine.com/medline/citation/483376/Leg_ulceration_in_sickle_cell_disease_in_Nigeria_ L2 - https://ClinicalTrials.gov/search/term=483376 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -