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Comparative trial of benzhexol, amantadine, and levodopa in the treatment of Parkinson's disease.
J Neurol Neurosurg Psychiatry. 1974 Apr; 37(4):422-6.JN

Abstract

Fourteen slightly disabled patients with Parkinsonism were treated separately with benzhexol, amantadine, and levodopa. Benzhexol and amantadine both gave a 15% reduction in functional disability and levodopa a 36% reduction. Benzhexol lessened the rigidity and improved the flexion of posture of Parkinson's disease, but had little or no effect on akinesia and tremor. Amantadine and levodopa caused improvement in all these symptoms. The combination of benzhexol and amantadine was as effective after four weeks of treatment as levodopa was after six months.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

4838913

Citation

Parkes, J D., et al. "Comparative Trial of Benzhexol, Amantadine, and Levodopa in the Treatment of Parkinson's Disease." Journal of Neurology, Neurosurgery, and Psychiatry, vol. 37, no. 4, 1974, pp. 422-6.
Parkes JD, Baxter RC, Marsden CD, et al. Comparative trial of benzhexol, amantadine, and levodopa in the treatment of Parkinson's disease. J Neurol Neurosurg Psychiatry. 1974;37(4):422-6.
Parkes, J. D., Baxter, R. C., Marsden, C. D., & Rees, J. E. (1974). Comparative trial of benzhexol, amantadine, and levodopa in the treatment of Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 37(4), 422-6.
Parkes JD, et al. Comparative Trial of Benzhexol, Amantadine, and Levodopa in the Treatment of Parkinson's Disease. J Neurol Neurosurg Psychiatry. 1974;37(4):422-6. PubMed PMID: 4838913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative trial of benzhexol, amantadine, and levodopa in the treatment of Parkinson's disease. AU - Parkes,J D, AU - Baxter,R C, AU - Marsden,C D, AU - Rees,J E, PY - 1974/4/1/pubmed PY - 1974/4/1/medline PY - 1974/4/1/entrez SP - 422 EP - 6 JF - Journal of neurology, neurosurgery, and psychiatry JO - J Neurol Neurosurg Psychiatry VL - 37 IS - 4 N2 - Fourteen slightly disabled patients with Parkinsonism were treated separately with benzhexol, amantadine, and levodopa. Benzhexol and amantadine both gave a 15% reduction in functional disability and levodopa a 36% reduction. Benzhexol lessened the rigidity and improved the flexion of posture of Parkinson's disease, but had little or no effect on akinesia and tremor. Amantadine and levodopa caused improvement in all these symptoms. The combination of benzhexol and amantadine was as effective after four weeks of treatment as levodopa was after six months. SN - 0022-3050 UR - https://www.unboundmedicine.com/medline/citation/4838913/Comparative_trial_of_benzhexol_amantadine_and_levodopa_in_the_treatment_of_Parkinson's_disease_ L2 - https://jnnp.bmj.com/lookup/pmidlookup?view=long&pmid=4838913 DB - PRIME DP - Unbound Medicine ER -