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An investigation of the antitumor activity of Micromelum integerrimum (Rutaceae).
J Nat Prod. 1979 May-Jun; 42(3):274-8.JN

Abstract

Extracts of Micromelum integerrimum (Buch.-Ham. ex Coleb.) M. Roem. were fractionated based on in vivo activity in mice in the P-388 lymphocytic leukemia system. Activity in ethanol extracts was concentrated in the chloroform partition fraction, which was further resolved by chromatography on silica gel. The known coumarins, micromelin and scopoletin, were crystallized from the active fractions and demonstrated to have antitumor activities. Micromelin was converted to the corresponding butenolide (deoxymicromelin) which was inactive in the 9KB assay.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

490172

Citation

Cassady, J M., et al. "An Investigation of the Antitumor Activity of Micromelum Integerrimum (Rutaceae)." Journal of Natural Products, vol. 42, no. 3, 1979, pp. 274-8.
Cassady JM, Ojima N, Chang C, et al. An investigation of the antitumor activity of Micromelum integerrimum (Rutaceae). J Nat Prod. 1979;42(3):274-8.
Cassady, J. M., Ojima, N., Chang, C., & McLaughlin, J. L. (1979). An investigation of the antitumor activity of Micromelum integerrimum (Rutaceae). Journal of Natural Products, 42(3), 274-8.
Cassady JM, et al. An Investigation of the Antitumor Activity of Micromelum Integerrimum (Rutaceae). J Nat Prod. 1979 May-Jun;42(3):274-8. PubMed PMID: 490172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An investigation of the antitumor activity of Micromelum integerrimum (Rutaceae). AU - Cassady,J M, AU - Ojima,N, AU - Chang,C, AU - McLaughlin,J L, PY - 1979/5/1/pubmed PY - 1979/5/1/medline PY - 1979/5/1/entrez SP - 274 EP - 8 JF - Journal of natural products JO - J Nat Prod VL - 42 IS - 3 N2 - Extracts of Micromelum integerrimum (Buch.-Ham. ex Coleb.) M. Roem. were fractionated based on in vivo activity in mice in the P-388 lymphocytic leukemia system. Activity in ethanol extracts was concentrated in the chloroform partition fraction, which was further resolved by chromatography on silica gel. The known coumarins, micromelin and scopoletin, were crystallized from the active fractions and demonstrated to have antitumor activities. Micromelin was converted to the corresponding butenolide (deoxymicromelin) which was inactive in the 9KB assay. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/490172/An_investigation_of_the_antitumor_activity_of_Micromelum_integerrimum__Rutaceae__ DB - PRIME DP - Unbound Medicine ER -