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Sialic acid secretion of patients with gastric and duodenal ulcers in the dose-response pentastrin test.
Ann Clin Res. 1979 Jun; 11(3):107-12.AC

Abstract

The secretion of HCl and sialic acid into the gastric juice was investigated in 13 patients with gastric, 52 with duodenal ulcers and 27 control patients, during the dose-response pentagastrin test. The basal output of sialic acid was clearly highest in patients with gastric ulcers, and the differences between these and other groups of patients were significant. During pentagastrin stimulation a significant initial decrease was found in patients with gastric ulcers with small doses, and the minimum was reached with a dose of 0.1 micrograms/kg/h. After increasing the dose, an increase in sialic acid output occurred in all groups, reaching its maximum with a pentagastrin infusion rate of 1.0 micrograms/kg/h. The basal concentration of sialic acid was also highest in patients with gastric ulcers. In all groups the concentration decreased during the stimulation, which obviously depended on the sialic output not increasing in the same relationship as the volume of gastric secretion.

Authors

Ala-Kaila K
No affiliation info available
Ahola T
No affiliation info available
Keyriläinen O
No affiliation info available
Uusitalo A
No affiliation info available

MeSH

AdultDose-Response Relationship, DrugDuodenal UlcerFemaleGastric JuiceHumansInfusions, ParenteralMaleMiddle AgedPentagastrinSecretory RateSialic AcidsStomach Ulcer

Pub Type(s)

Journal Article

Language

eng

PubMed ID

496372

Citation

Ala-Kaila, K, et al. "Sialic Acid Secretion of Patients With Gastric and Duodenal Ulcers in the Dose-response Pentastrin Test." Annals of Clinical Research, vol. 11, no. 3, 1979, pp. 107-12.
Ala-Kaila K, Ahola T, Keyriläinen O, et al. Sialic acid secretion of patients with gastric and duodenal ulcers in the dose-response pentastrin test. Ann Clin Res. 1979;11(3):107-12.
Ala-Kaila, K., Ahola, T., Keyriläinen, O., & Uusitalo, A. (1979). Sialic acid secretion of patients with gastric and duodenal ulcers in the dose-response pentastrin test. Annals of Clinical Research, 11(3), 107-12.
Ala-Kaila K, et al. Sialic Acid Secretion of Patients With Gastric and Duodenal Ulcers in the Dose-response Pentastrin Test. Ann Clin Res. 1979;11(3):107-12. PubMed PMID: 496372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sialic acid secretion of patients with gastric and duodenal ulcers in the dose-response pentastrin test. AU - Ala-Kaila,K, AU - Ahola,T, AU - Keyriläinen,O, AU - Uusitalo,A, PY - 1979/6/1/pubmed PY - 1979/6/1/medline PY - 1979/6/1/entrez SP - 107 EP - 12 JF - Annals of clinical research JO - Ann Clin Res VL - 11 IS - 3 N2 - The secretion of HCl and sialic acid into the gastric juice was investigated in 13 patients with gastric, 52 with duodenal ulcers and 27 control patients, during the dose-response pentagastrin test. The basal output of sialic acid was clearly highest in patients with gastric ulcers, and the differences between these and other groups of patients were significant. During pentagastrin stimulation a significant initial decrease was found in patients with gastric ulcers with small doses, and the minimum was reached with a dose of 0.1 micrograms/kg/h. After increasing the dose, an increase in sialic acid output occurred in all groups, reaching its maximum with a pentagastrin infusion rate of 1.0 micrograms/kg/h. The basal concentration of sialic acid was also highest in patients with gastric ulcers. In all groups the concentration decreased during the stimulation, which obviously depended on the sialic output not increasing in the same relationship as the volume of gastric secretion. SN - 0003-4762 UR - https://www.unboundmedicine.com/medline/citation/496372/Sialic_acid_secretion_of_patients_with_gastric_and_duodenal_ulcers_in_the_dose_response_pentastrin_test_ DB - PRIME DP - Unbound Medicine ER -