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Pharmacokinetics and pharmacodynamics of warfarin at steady state.
Br J Clin Pharmacol. 1979 Sep; 8(3):243-7.BJ

Abstract

1 The relationship between warfarin dose, total and free plasma warfarin concentration, and anticoagulant effect was examined at several steady-state levels in fifteen patients during withdrawal of warfarin therapy. 2 Total plasma clearance was significantly correlated with the free fraction in plasma (r=0.955). 3 There was an age related decline in the dose of warfarin, and in the total and free plasma warfarin concentrations required to produce the same anticoagulant effect. However, neither total nor free plasma warfarin clearances varied with age. 4 Individual patients' log concentration-effect relationships were linear above a prothrombin ratio of 1.2 and there was a significant correlation (r=-0.586) between the slope and the free fraction of warfarin in plasma. It is suggested that plasma protein binding may reflect the interaction between warfarin and its effector site in the hepatocyte.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

497091

Citation

Routledge, P A., et al. "Pharmacokinetics and Pharmacodynamics of Warfarin at Steady State." British Journal of Clinical Pharmacology, vol. 8, no. 3, 1979, pp. 243-7.
Routledge PA, Chapman PH, Davies DM, et al. Pharmacokinetics and pharmacodynamics of warfarin at steady state. Br J Clin Pharmacol. 1979;8(3):243-7.
Routledge, P. A., Chapman, P. H., Davies, D. M., & Rawlins, M. D. (1979). Pharmacokinetics and pharmacodynamics of warfarin at steady state. British Journal of Clinical Pharmacology, 8(3), 243-7.
Routledge PA, et al. Pharmacokinetics and Pharmacodynamics of Warfarin at Steady State. Br J Clin Pharmacol. 1979;8(3):243-7. PubMed PMID: 497091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetics and pharmacodynamics of warfarin at steady state. AU - Routledge,P A, AU - Chapman,P H, AU - Davies,D M, AU - Rawlins,M D, PY - 1979/9/1/pubmed PY - 1979/9/1/medline PY - 1979/9/1/entrez SP - 243 EP - 7 JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 8 IS - 3 N2 - 1 The relationship between warfarin dose, total and free plasma warfarin concentration, and anticoagulant effect was examined at several steady-state levels in fifteen patients during withdrawal of warfarin therapy. 2 Total plasma clearance was significantly correlated with the free fraction in plasma (r=0.955). 3 There was an age related decline in the dose of warfarin, and in the total and free plasma warfarin concentrations required to produce the same anticoagulant effect. However, neither total nor free plasma warfarin clearances varied with age. 4 Individual patients' log concentration-effect relationships were linear above a prothrombin ratio of 1.2 and there was a significant correlation (r=-0.586) between the slope and the free fraction of warfarin in plasma. It is suggested that plasma protein binding may reflect the interaction between warfarin and its effector site in the hepatocyte. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/497091/Pharmacokinetics_and_pharmacodynamics_of_warfarin_at_steady_state_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0306-5251&date=1979&volume=8&issue=3&spage=243 DB - PRIME DP - Unbound Medicine ER -