TY - JOUR T1 - Coagulolysis assay in the detection of deep vein thrombosis in the orthopedic patient. A preliminary report. AU - Steves,C R, AU - Kopta,J A, AU - Taylor,F B, AU - Jacocks,R, AU - Comp,P C, PY - 1979/7/1/pubmed PY - 1979/7/1/medline PY - 1979/7/1/entrez SP - 190 EP - 5 JF - Clinical orthopaedics and related research JO - Clin Orthop Relat Res IS - 142 N2 - The recently developed coagulolysis assay was utilized in conjuction with fibrinogen uptake scanning to monitor 91 of 111 consecutive orthopedic patients scheduled for hip surgery or total knee replacement. Sixteen patients had abnormal coagulolysis assays and positive scans. Venography was performed in 15 of these patients, and deep vein thrombosis was documented in 12. Five patients developed pulmonary emboli, including one with negative venogram. Thus, over 80% of the patients in which both the coagulolysis assay and the fibrinogen scan were abnormal had additional documentation of deep vein thrombosis. In 41 patients, the coagulolysis assay was negative. Venograms were not routinely performed in this group. However, 3 patients developed pulmonary emboli indicating that deep vein thrombosis developed in this group. Only one patient had a normal coagulolysis with a positive fibrinogen scan. Venography documented a deep vein thrombosis. Thirty-three patients who had normal coagulolysis assays and negative fibrinogen scans also had no evidence of deep vein thrombosis or pulmonary embolism. The coagulolysis assay appears to be a safe, noninvasive study for the detection of deep vein thrombosis. There was only a one per cent false-negative incidence. SN - 0009-921X UR - https://www.unboundmedicine.com/medline/citation/498636/Coagulolysis_assay_in_the_detection_of_deep_vein_thrombosis_in_the_orthopedic_patient__A_preliminary_report_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=498636.ui DB - PRIME DP - Unbound Medicine ER -