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The control of iron absorption by the gastrointestinal mucosal cell.
J Clin Invest. 1972 Feb; 51(2):224-31.JCI

Abstract

Gastrointestinal mucosal factors controlling rates of iron absorption were studied utilizing an in vivo closed duodenal loop technique. Cellular distribution of newly absorbed radioiron was identified by molecular sieve and iron-exchange chromatography of the mucosal cell supernate. In the normal animal, iron rapidly appeared in ferritin, and this fraction accounted for greater than 90% of mucosal supernatant radioactivity after 60 min absorption time. The nonferritin radioiron appeared to be unbound iron salts. In the presence of increased iron absorption induced by iron depletion or hemolysis, the major difference from the normal distribution pattern was an increase in the proportion and quantity of the free iron salts. Incorporation of newly absorbed iron into ferritin did not correlate with the rate of iron absorption. No evidence was found for a specific soluble iron-chelating molecule within the mucosal cell. The nonheme iron content of the mucosal supernates from iron-deficient and hemolyzing animals were significantly lower than in the normal animal.The data are consistent with hypotheses which suggest that iron absorption rates may be controlled in part by the rate of initial iron uptake by the mucosal cell and that a membrane transport mechanism exists which is modulated by the nonheme iron content of the mucosal cell or some portion thereof.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

5009111

Citation

Sheehan, R G., and E P. Frenkel. "The Control of Iron Absorption By the Gastrointestinal Mucosal Cell." The Journal of Clinical Investigation, vol. 51, no. 2, 1972, pp. 224-31.
Sheehan RG, Frenkel EP. The control of iron absorption by the gastrointestinal mucosal cell. J Clin Invest. 1972;51(2):224-31.
Sheehan, R. G., & Frenkel, E. P. (1972). The control of iron absorption by the gastrointestinal mucosal cell. The Journal of Clinical Investigation, 51(2), 224-31.
Sheehan RG, Frenkel EP. The Control of Iron Absorption By the Gastrointestinal Mucosal Cell. J Clin Invest. 1972;51(2):224-31. PubMed PMID: 5009111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The control of iron absorption by the gastrointestinal mucosal cell. AU - Sheehan,R G, AU - Frenkel,E P, PY - 1972/2/1/pubmed PY - 1972/2/1/medline PY - 1972/2/1/entrez SP - 224 EP - 31 JF - The Journal of clinical investigation JO - J Clin Invest VL - 51 IS - 2 N2 - Gastrointestinal mucosal factors controlling rates of iron absorption were studied utilizing an in vivo closed duodenal loop technique. Cellular distribution of newly absorbed radioiron was identified by molecular sieve and iron-exchange chromatography of the mucosal cell supernate. In the normal animal, iron rapidly appeared in ferritin, and this fraction accounted for greater than 90% of mucosal supernatant radioactivity after 60 min absorption time. The nonferritin radioiron appeared to be unbound iron salts. In the presence of increased iron absorption induced by iron depletion or hemolysis, the major difference from the normal distribution pattern was an increase in the proportion and quantity of the free iron salts. Incorporation of newly absorbed iron into ferritin did not correlate with the rate of iron absorption. No evidence was found for a specific soluble iron-chelating molecule within the mucosal cell. The nonheme iron content of the mucosal supernates from iron-deficient and hemolyzing animals were significantly lower than in the normal animal.The data are consistent with hypotheses which suggest that iron absorption rates may be controlled in part by the rate of initial iron uptake by the mucosal cell and that a membrane transport mechanism exists which is modulated by the nonheme iron content of the mucosal cell or some portion thereof. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/5009111/The_control_of_iron_absorption_by_the_gastrointestinal_mucosal_cell_ L2 - https://doi.org/10.1172/JCI106807 DB - PRIME DP - Unbound Medicine ER -