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Immunologic activity of myelin basic protein in strain 2 and strain 13 guinea pigs.
J Immunol. 1975 Jul; 115(1):75-9.JI

Abstract

The resistance of Strain 2 guinea pigs to experimental allergic encephalomyelitis (EAE) induced by inoculation with whole CNS tissue in complete Freund's adjuvant (CFA) has been confirmed. The resistance is even more pronounced when myelin basic protein (BP) is used in attempts to induce EAE. Strain 2 guinea pigs are also resistant to an immunization schedule (multiple injections with BP in IFA followed by a single injection of BP in CFA) known to induce significant levels of antibody in susceptible strains. The poor response of Strain 2 guinea pigs to BP is not the result of lack of specific B cells--antibody equivalent to that produced by Strain 13 animals is obtained when the inoculum contains 0.5 mg BP and 2.5 mycobacteria.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

50359

Citation

Kies, M W., et al. "Immunologic Activity of Myelin Basic Protein in Strain 2 and Strain 13 Guinea Pigs." Journal of Immunology (Baltimore, Md. : 1950), vol. 115, no. 1, 1975, pp. 75-9.
Kies MW, Driscoll BF, Lisak RP, et al. Immunologic activity of myelin basic protein in strain 2 and strain 13 guinea pigs. J Immunol. 1975;115(1):75-9.
Kies, M. W., Driscoll, B. F., Lisak, R. P., & Alvord, E. C. (1975). Immunologic activity of myelin basic protein in strain 2 and strain 13 guinea pigs. Journal of Immunology (Baltimore, Md. : 1950), 115(1), 75-9.
Kies MW, et al. Immunologic Activity of Myelin Basic Protein in Strain 2 and Strain 13 Guinea Pigs. J Immunol. 1975;115(1):75-9. PubMed PMID: 50359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunologic activity of myelin basic protein in strain 2 and strain 13 guinea pigs. AU - Kies,M W, AU - Driscoll,B F, AU - Lisak,R P, AU - Alvord,E C,Jr PY - 1975/7/1/pubmed PY - 2001/3/28/medline PY - 1975/7/1/entrez SP - 75 EP - 9 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 115 IS - 1 N2 - The resistance of Strain 2 guinea pigs to experimental allergic encephalomyelitis (EAE) induced by inoculation with whole CNS tissue in complete Freund's adjuvant (CFA) has been confirmed. The resistance is even more pronounced when myelin basic protein (BP) is used in attempts to induce EAE. Strain 2 guinea pigs are also resistant to an immunization schedule (multiple injections with BP in IFA followed by a single injection of BP in CFA) known to induce significant levels of antibody in susceptible strains. The poor response of Strain 2 guinea pigs to BP is not the result of lack of specific B cells--antibody equivalent to that produced by Strain 13 animals is obtained when the inoculum contains 0.5 mg BP and 2.5 mycobacteria. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/50359/Immunologic_activity_of_myelin_basic_protein_in_strain_2_and_strain_13_guinea_pigs_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=50359 DB - PRIME DP - Unbound Medicine ER -