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Effects of adenosine-5'-triphosphate (ATP) on rat mast cells: influence on anaphylactic and compound 48/80-induced histamine release.
Agents Actions. 1975 May; 5(2):108-14.AA

Abstract

Anaphylactic histamine release from mast cells isolated from actively sensitized rats was inhibited by pre-incubation with micromolar concentrations of ATP. The inhibition was reversible under various experimental conditions and was counteracted by the presence of calcium in the incubation medium. Histamine release induced by compound 48/80 was similarly affected. Mast cells exposed to antigen under conditions when histamine release was inhibited by ATP became desensitized. The results indicate that ATP inhibits the release mechanism at a step which occurs after the binding of antigen to IgE.

Authors

Grosman N
No affiliation info available
Diamant B
No affiliation info available

MeSH

Adenosine TriphosphateAnaphylaxisAnimalsCalciumFemaleHistamine ReleaseMast CellsRatsTime Factorsp-Methoxy-N-methylphenethylamine

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

50722

Citation

Grosman, N, and B Diamant. "Effects of Adenosine-5'-triphosphate (ATP) On Rat Mast Cells: Influence On Anaphylactic and Compound 48/80-induced Histamine Release." Agents and Actions, vol. 5, no. 2, 1975, pp. 108-14.
Grosman N, Diamant B. Effects of adenosine-5'-triphosphate (ATP) on rat mast cells: influence on anaphylactic and compound 48/80-induced histamine release. Agents Actions. 1975;5(2):108-14.
Grosman, N., & Diamant, B. (1975). Effects of adenosine-5'-triphosphate (ATP) on rat mast cells: influence on anaphylactic and compound 48/80-induced histamine release. Agents and Actions, 5(2), 108-14.
Grosman N, Diamant B. Effects of Adenosine-5'-triphosphate (ATP) On Rat Mast Cells: Influence On Anaphylactic and Compound 48/80-induced Histamine Release. Agents Actions. 1975;5(2):108-14. PubMed PMID: 50722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of adenosine-5'-triphosphate (ATP) on rat mast cells: influence on anaphylactic and compound 48/80-induced histamine release. AU - Grosman,N, AU - Diamant,B, PY - 1975/5/1/pubmed PY - 1975/5/1/medline PY - 1975/5/1/entrez SP - 108 EP - 14 JF - Agents and actions JO - Agents Actions VL - 5 IS - 2 N2 - Anaphylactic histamine release from mast cells isolated from actively sensitized rats was inhibited by pre-incubation with micromolar concentrations of ATP. The inhibition was reversible under various experimental conditions and was counteracted by the presence of calcium in the incubation medium. Histamine release induced by compound 48/80 was similarly affected. Mast cells exposed to antigen under conditions when histamine release was inhibited by ATP became desensitized. The results indicate that ATP inhibits the release mechanism at a step which occurs after the binding of antigen to IgE. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/50722/Effects_of_adenosine_5'_triphosphate__ATP__on_rat_mast_cells:_influence_on_anaphylactic_and_compound_48/80_induced_histamine_release_ DB - PRIME DP - Unbound Medicine ER -