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Chloramphenicol combined with ampicillin in treatment of typhoid.
Br Med J. 1972 Oct 07; 4(5831):17-8.BM

Abstract

Fifty out of 100 patients with typhoid fever, matched for age, stage of illness, and degree of fever, were treated with chloramphenicol and the other 50 were treated with chloramphenicol combined with ampicillin. The febrile period was shortened by up to 29% in patients treated with the combined drugs compared with those given only chloramphenicol. Moreover, no patient on combined therapy had a febrile relapse, whereas two relapses occurred among patients treated with chloramphenicol only. We conclude that chloramphenicol and ampicillin together are better than chloramphenicol alone in the treatment of typhoid fever.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

5078403

Citation

De Ritis, F, et al. "Chloramphenicol Combined With Ampicillin in Treatment of Typhoid." British Medical Journal, vol. 4, no. 5831, 1972, pp. 17-8.
De Ritis F, Giammanco G, Manzillo G. Chloramphenicol combined with ampicillin in treatment of typhoid. Br Med J. 1972;4(5831):17-8.
De Ritis, F., Giammanco, G., & Manzillo, G. (1972). Chloramphenicol combined with ampicillin in treatment of typhoid. British Medical Journal, 4(5831), 17-8.
De Ritis F, Giammanco G, Manzillo G. Chloramphenicol Combined With Ampicillin in Treatment of Typhoid. Br Med J. 1972 Oct 7;4(5831):17-8. PubMed PMID: 5078403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chloramphenicol combined with ampicillin in treatment of typhoid. AU - De Ritis,F, AU - Giammanco,G, AU - Manzillo,G, PY - 1972/10/7/pubmed PY - 1972/10/7/medline PY - 1972/10/7/entrez SP - 17 EP - 8 JF - British medical journal JO - Br Med J VL - 4 IS - 5831 N2 - Fifty out of 100 patients with typhoid fever, matched for age, stage of illness, and degree of fever, were treated with chloramphenicol and the other 50 were treated with chloramphenicol combined with ampicillin. The febrile period was shortened by up to 29% in patients treated with the combined drugs compared with those given only chloramphenicol. Moreover, no patient on combined therapy had a febrile relapse, whereas two relapses occurred among patients treated with chloramphenicol only. We conclude that chloramphenicol and ampicillin together are better than chloramphenicol alone in the treatment of typhoid fever. SN - 0007-1447 UR - https://www.unboundmedicine.com/medline/citation/5078403/Chloramphenicol_combined_with_ampicillin_in_treatment_of_typhoid_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/5078403/ DB - PRIME DP - Unbound Medicine ER -