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Cutaneous vascular histamine H1 and H2 receptors in the guinea-pig: the histamine skin wheal as a cutaneous vascular model.
Arch Int Pharmacodyn Ther. 1979 Aug; 240(2):214-9.AI

Abstract

The roles of histamine H1 and H2 receptors in histamine skin wheals were studied in the guinea-pig. Intradermal injections of histamine, 0.125--2 micrograms/0.1 ml, produced wheals in a dose dependent manner. Pyrilamine maleate (3.2 mg/kg p.o., pretreatment for 1 hour) produced a dose dependent shift of the histamine wheal dose-response curve to the right in a parallel fashion. Metiamide, 3, 10 or 30 mg/kg p.o., had no effect on the histamine dose-response curve. However, a combination of metiamide (10 or 30 mg/kg) and pyrilamine (3.2 mg/kg) further increased the effect of pyrilamine. It is concluded that both H1 and H2 receptors are involved in histamine-induced wheals in the guinea-pig.

Authors

Cheng HC
No affiliation info available
Reavis OK
No affiliation info available
Munro NL
No affiliation info available
Woodward JK
No affiliation info available

MeSH

AnimalsDose-Response Relationship, DrugDrug InteractionsGuinea PigsHistamineMetiamidePyrilamineReceptors, HistamineReceptors, Histamine H1Receptors, Histamine H2SkinSkin Tests

Pub Type(s)

Journal Article

Language

eng

PubMed ID

508005

Citation

Cheng, H C., et al. "Cutaneous Vascular Histamine H1 and H2 Receptors in the Guinea-pig: the Histamine Skin Wheal as a Cutaneous Vascular Model." Archives Internationales De Pharmacodynamie Et De Therapie, vol. 240, no. 2, 1979, pp. 214-9.
Cheng HC, Reavis OK, Munro NL, et al. Cutaneous vascular histamine H1 and H2 receptors in the guinea-pig: the histamine skin wheal as a cutaneous vascular model. Arch Int Pharmacodyn Ther. 1979;240(2):214-9.
Cheng, H. C., Reavis, O. K., Munro, N. L., & Woodward, J. K. (1979). Cutaneous vascular histamine H1 and H2 receptors in the guinea-pig: the histamine skin wheal as a cutaneous vascular model. Archives Internationales De Pharmacodynamie Et De Therapie, 240(2), 214-9.
Cheng HC, et al. Cutaneous Vascular Histamine H1 and H2 Receptors in the Guinea-pig: the Histamine Skin Wheal as a Cutaneous Vascular Model. Arch Int Pharmacodyn Ther. 1979;240(2):214-9. PubMed PMID: 508005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutaneous vascular histamine H1 and H2 receptors in the guinea-pig: the histamine skin wheal as a cutaneous vascular model. AU - Cheng,H C, AU - Reavis,O K,Jr AU - Munro,N L, AU - Woodward,J K, PY - 1979/8/1/pubmed PY - 2001/3/28/medline PY - 1979/8/1/entrez SP - 214 EP - 9 JF - Archives internationales de pharmacodynamie et de therapie JO - Arch Int Pharmacodyn Ther VL - 240 IS - 2 N2 - The roles of histamine H1 and H2 receptors in histamine skin wheals were studied in the guinea-pig. Intradermal injections of histamine, 0.125--2 micrograms/0.1 ml, produced wheals in a dose dependent manner. Pyrilamine maleate (3.2 mg/kg p.o., pretreatment for 1 hour) produced a dose dependent shift of the histamine wheal dose-response curve to the right in a parallel fashion. Metiamide, 3, 10 or 30 mg/kg p.o., had no effect on the histamine dose-response curve. However, a combination of metiamide (10 or 30 mg/kg) and pyrilamine (3.2 mg/kg) further increased the effect of pyrilamine. It is concluded that both H1 and H2 receptors are involved in histamine-induced wheals in the guinea-pig. SN - 0003-9780 UR - https://www.unboundmedicine.com/medline/citation/508005/Cutaneous_vascular_histamine_H1_and_H2_receptors_in_the_guinea_pig:_the_histamine_skin_wheal_as_a_cutaneous_vascular_model_ DB - PRIME DP - Unbound Medicine ER -