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Adaptation to ethanol-induced fluidization of brain lipid bilayers.
Drug Alcohol Depend. 1979 Jan-Mar; 4(1-2):197-202.DA

Abstract

We have shown that ethanol is less able to fluidize reconstituted membranes prepared from lipid extracts of tolerant mice synaptosomal membranes than those prepared from controls. The effects of ethanol on membrane fluidity were assessed by fluorescence polarization technique. Acute in vivo administration of ethanol did not alter ethanol-induced fluidization of the bilayers. These results suggest that changes in the lipid composition of membranes can account, at least in part, for tissue adaptation to ethanol-induced membrane fluidization. We also discuss the use of reconstituted membranes as a tool both to analyze the significance of changes in membrane composition for the development of tolerance and to refine our concepts concerning the relation between membrane fluidity and anesthetic activity.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

510172

Citation

Johnson, D A., et al. "Adaptation to Ethanol-induced Fluidization of Brain Lipid Bilayers." Drug and Alcohol Dependence, vol. 4, no. 1-2, 1979, pp. 197-202.
Johnson DA, Lee NM, Cooke R. Adaptation to ethanol-induced fluidization of brain lipid bilayers. Drug Alcohol Depend. 1979;4(1-2):197-202.
Johnson, D. A., Lee, N. M., & Cooke, R. (1979). Adaptation to ethanol-induced fluidization of brain lipid bilayers. Drug and Alcohol Dependence, 4(1-2), 197-202.
Johnson DA, Lee NM, Cooke R. Adaptation to Ethanol-induced Fluidization of Brain Lipid Bilayers. Drug Alcohol Depend. 1979 Jan-Mar;4(1-2):197-202. PubMed PMID: 510172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adaptation to ethanol-induced fluidization of brain lipid bilayers. AU - Johnson,D A, AU - Lee,N M, AU - Cooke,R, PY - 1979/1/1/pubmed PY - 1979/1/1/medline PY - 1979/1/1/entrez SP - 197 EP - 202 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 4 IS - 1-2 N2 - We have shown that ethanol is less able to fluidize reconstituted membranes prepared from lipid extracts of tolerant mice synaptosomal membranes than those prepared from controls. The effects of ethanol on membrane fluidity were assessed by fluorescence polarization technique. Acute in vivo administration of ethanol did not alter ethanol-induced fluidization of the bilayers. These results suggest that changes in the lipid composition of membranes can account, at least in part, for tissue adaptation to ethanol-induced membrane fluidization. We also discuss the use of reconstituted membranes as a tool both to analyze the significance of changes in membrane composition for the development of tolerance and to refine our concepts concerning the relation between membrane fluidity and anesthetic activity. SN - 0376-8716 UR - https://www.unboundmedicine.com/medline/citation/510172/Adaptation_to_ethanol_induced_fluidization_of_brain_lipid_bilayers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0376-8716(79)90067-X DB - PRIME DP - Unbound Medicine ER -