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The utilization of adenosine triphosphate in rat mast cells during histamine release induced by anaphylactic reaction and compound 48/80.
Naunyn Schmiedebergs Arch Pharmacol. 1975; 288(2-3):243-60.NS

Abstract

The ATP content of rat peritoneal mast cells has been studied in relation to histamine release induced by compound 48/80 and antigen-antibody (anaphylactic) reaction in vitro. When the ATP content of actively sensitized mast cells was reduced to different levels by oligomycin, a good correlation was obtained between the ATP levels and the amounts of histamine released by the anaphylactic reaction. A similar linear relation has previously been demonstrated between the ATP levels of mast cells and histamine release induced by compound 48/80. The ATP content of mast cells was also studied at different intervals after the exposure of the cells to antigen or compound 48/80. No significant change in the ATP content was observed in untreated mast cells during the short period when histamine release occurs. If, however, the mast cells were preincubated with oligomycin or 2-deoxyglucose to reduce the rate of ATP synthesis while a large part of the histamine release remained unaffected-a decrease in the ATP content could be demonstrated in close time relation to both anaphylactic and compound 48/80-induced histamine release. The observations indicate an increased utilization of ATP in mast cells during the release process.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

51482

Citation

Johansen, T, and N Chakravarty. "The Utilization of Adenosine Triphosphate in Rat Mast Cells During Histamine Release Induced By Anaphylactic Reaction and Compound 48/80." Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 288, no. 2-3, 1975, pp. 243-60.
Johansen T, Chakravarty N. The utilization of adenosine triphosphate in rat mast cells during histamine release induced by anaphylactic reaction and compound 48/80. Naunyn Schmiedebergs Arch Pharmacol. 1975;288(2-3):243-60.
Johansen, T., & Chakravarty, N. (1975). The utilization of adenosine triphosphate in rat mast cells during histamine release induced by anaphylactic reaction and compound 48/80. Naunyn-Schmiedeberg's Archives of Pharmacology, 288(2-3), 243-60.
Johansen T, Chakravarty N. The Utilization of Adenosine Triphosphate in Rat Mast Cells During Histamine Release Induced By Anaphylactic Reaction and Compound 48/80. Naunyn Schmiedebergs Arch Pharmacol. 1975;288(2-3):243-60. PubMed PMID: 51482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The utilization of adenosine triphosphate in rat mast cells during histamine release induced by anaphylactic reaction and compound 48/80. AU - Johansen,T, AU - Chakravarty,N, PY - 1975/1/1/pubmed PY - 1975/1/1/medline PY - 1975/1/1/entrez SP - 243 EP - 60 JF - Naunyn-Schmiedeberg's archives of pharmacology JO - Naunyn Schmiedebergs Arch Pharmacol VL - 288 IS - 2-3 N2 - The ATP content of rat peritoneal mast cells has been studied in relation to histamine release induced by compound 48/80 and antigen-antibody (anaphylactic) reaction in vitro. When the ATP content of actively sensitized mast cells was reduced to different levels by oligomycin, a good correlation was obtained between the ATP levels and the amounts of histamine released by the anaphylactic reaction. A similar linear relation has previously been demonstrated between the ATP levels of mast cells and histamine release induced by compound 48/80. The ATP content of mast cells was also studied at different intervals after the exposure of the cells to antigen or compound 48/80. No significant change in the ATP content was observed in untreated mast cells during the short period when histamine release occurs. If, however, the mast cells were preincubated with oligomycin or 2-deoxyglucose to reduce the rate of ATP synthesis while a large part of the histamine release remained unaffected-a decrease in the ATP content could be demonstrated in close time relation to both anaphylactic and compound 48/80-induced histamine release. The observations indicate an increased utilization of ATP in mast cells during the release process. SN - 0028-1298 UR - https://www.unboundmedicine.com/medline/citation/51482/The_utilization_of_adenosine_triphosphate_in_rat_mast_cells_during_histamine_release_induced_by_anaphylactic_reaction_and_compound_48/80_ DB - PRIME DP - Unbound Medicine ER -